{"product_id":"abcam-ab85491","title":"Abcam, ab85491, Anti-CaV1.3 antibody [S48]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal CaV1.3 antibody. N-terminal. Suitable for Flow Cyt, IHC-P and reacts with Human, Mouse samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Rat Cacna1d aa 850-900.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:S48,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:Flow Cyt, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Rat Cacna1d aa 850-900. The exact immunogen used to generate this antibody is proprietary information.P27732,\u003cbr\u003e\nSpecificity:No cross reactivity against CaV1.2.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe clone number has been updated from S48A-9 to L48A\/9, both clone numbers name the same antibody clone.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCaV1.3 also known as CACNA1D is a type of L-type voltage-gated calcium channel. It displays a molecular mass of around 250 kDa. This protein predominantly functions in the central nervous system heart and pancreas. It plays an important role in calcium ion influx which is critical for various physiological processes. CaV1.3 channels like other L-type channels are sensitive to dihydropyridines which are commonly used in antihypertensive therapies.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCaV1.3 channels contribute to the electrical excitability and signaling in cells. They are involved in muscle contraction neurotransmitter release and gene expression. CaV1.3 is part of a calcium signaling complex that tightly regulates intracellular calcium concentration. It interacts with other cellular components to achieve precise control over calcium-dependent processes which is critical for maintaining cellular homeostasis and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nCaV1.3 channels play significant roles in the excitation-contraction coupling pathway in cardiac muscle cells and the insulin secretion pathway in pancreatic beta cells. Their function is closely related to other voltage-gated calcium channels like CaV1.2 which are also part of the calcium signaling pathway. These channels ensure that physiological functions requiring rapid calcium signaling occur efficiently.\u003cbr\u003e\nCaV1.3 is linked to various conditions including cardiac arrhythmias and neurodegenerative diseases such as Parkinson's disease. Dysregulation of CaV1.3 expression or function may lead to abnormal calcium signaling. In Parkinson's disease altered CaV1.3 activity affects dopaminergic neurons with potential involvement of alpha-synuclein a protein that aggregates in the disease. Understanding these connections provides insights into potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845024370857,"sku":"ab85491","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab85491","provider":"Iright","version":"1.0","type":"link"}