{"product_id":"abcam-ab87939","title":"Abcam, ab87939, Anti-PIWIL4\/PIWI antibody","description":"\u003cp\u003eSize: 200µL\u003cbr\u003e\nRabbit Polyclonal PIWIL4\/PIWI antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PIWIL4.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PIWIL4. The exact immunogen used to generate this antibody is proprietary information.Q7Z3Z4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 2% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPIWIL4 also known as PIWI-like 4 is a protein involved in RNA-mediated gene silencing with a molecular weight of approximately 97 kDa. It is expressed mostly in germ cell tissues including the testes and ovaries. PIWIL4 belongs to the PIWI subfamily of Argonaute proteins which is critical for the regulation of gene expression at the transcriptional and post-transcriptional levels.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPIWIL4 plays an important role in the process of germ cell development and maintenance. It is essential for the formation of piRNA clusters and interacts with small non-coding RNA known as PIWI-interacting RNA (piRNA). It functions as part of a protein complex that facilitates the silencing of transposable elements and the regulation of gene expression therefore safeguarding genome integrity in germ cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nPIWIL4 integrates within the piRNA biogenesis pathway and RNA interference (RNAi) pathway key processes in cellular defense mechanisms. It associates with other PIWI family members such as PIWIL1 and PIWIL2 which collaborate to cleave and silence transposable elements and undesirable genetic elements. This function is critical in pausing transposition events that can disrupt genomic stability.\u003cbr\u003e\nPIWIL4 has connections to certain cancers such as testicular germ cell tumor due to its role in regulating cell proliferation and genome protection. Abnormal expression or malfunction of PIWIL4 has implications in the development of infertility as it influences germ cell maturation. Investigations also assess its interactions with proteins like MAEL and TDRD1 which contribute to the maintenance of spermatogenic functions in testicular tissues.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850081521833,"sku":"ab87939","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab87939","provider":"Iright","version":"1.0","type":"link"}