{"product_id":"abcam-ab87977","title":"Abcam, ab87977, Anti-MGAT5 antibody [3E9]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal MGAT5 antibody. Carrier free. Suitable for Flow Cyt, WB and reacts with Human, Recombinant fragment - Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MGAT5 aa 600 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:3E9,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MGAT5 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q09328\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was changed from ascites to tissue culture supernatant on 15 May 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Purification notes-Purified from TCS., Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMGAT5 also known as beta-16-N-acetylglucosaminyltransferase V or GnT-V is an enzyme with a molecular mass of approximately 83 kDa. This enzyme plays a role in the Golgi apparatus where it modifies N-glycans on glycoproteins by adding N-acetylglucosamine to N-glycans. MGAT5 is expressed in various tissues including the brain liver and kidneys. Its enzymatic function is essential in creating complex branched glycan structures influencing the cellular surface glycosylation patterns.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMGAT5 contributes to cellular processes such as cell-cell communication cell migration and signal transduction. These processes are important in tissues where it is expressed. MGAT5 is not part of a complex but works closely with other glycosyltransferases in the glycosylation pathway. Its glycan products interact with lectins and receptors on the cell surface influencing signaling pathways and cellular behavior.\u003cbr\u003e\nPathways\u003cbr\u003e\nMGAT5 is significant in the glycosylation pathway and the PI3K\/AKT signaling pathway. In these pathways MGAT5 modifies glycoproteins which can impact receptor function and downstream signaling. It interacts with proteins such as integrins and growth factor receptors affecting cellular responses to environmental cues and influencing growth and differentiation signals.\u003cbr\u003e\nMGAT5 is associated with cancer progression and autoimmune diseases. Altered MGAT5 expression and activity in cancer cells can promote tumor growth and metastasis by enhancing cell invasion and evasion mechanisms. The enzyme links to proteins like TGF-beta receptor and E-cadherin in cancer contributing to the changes in cellular adhesion and signaling that facilitate metastasis. In autoimmune diseases MGAT5 modulates immune cell function impacting disease progression and severity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855410024617,"sku":"ab87977","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab87977","provider":"Iright","version":"1.0","type":"link"}