{"product_id":"abcam-ab88249","title":"Abcam, ab88249, Anti-RECK antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal RECK antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RECK.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human RECK.O95980\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRECK also known as Reversion-inducing-cysteine-rich protein with kazal motifs is a 110 kDa membrane-anchored glycoprotein. It plays a role in inhibiting matrix metalloproteinases (MMPs) like MMP-2 and MMP-9 which are involved in extracellular matrix remodeling. RECK is widely expressed in various tissues including the brain heart and muscles. It interacts with other membrane proteins to modulate different cellular functions playing a part in maintaining the structure of tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRECK supports angiogenesis and tissue integrity by controlling matrix degradation. It is essential for proper vascular development. Although RECK is not part of a bigger complex it exerts its function by partnering with integrins and other membrane components. This interaction helps regulate cell migration and adhesion which are significant for normal development and wound healing processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nRECK engages in the regulation of the extracellular matrix and signaling cascades. It aligns with critical pathways like the Wnt and Rho GTPase pathways. These pathways are important in controlling cellular proliferation and movement. RECK's interaction with proteins like β-catenin and Ras further illustrates its importance in modulating cellular pathways connected to growth and movement.\u003cbr\u003e\nRECK can affect cancer progression and metastasis. Its downregulation or malfunction is associated with increased tumor invasion and angiogenesis due to uncontrolled MMP activity. RECK's connection with MMP-2 and MMP-9 is significant here as these proteins promote tumor metastasis. Its role is also evident in neurological disorders like cerebral ischemia where defective matrix remodeling can exacerbate tissue damage. Researchers focus on RECK to develop strategies for cancer therapeutics and neuroprotective treatments.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852269375657,"sku":"ab88249","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab88249","provider":"Iright","version":"1.0","type":"link"}