{"product_id":"abcam-ab88975","title":"Abcam, ab88975, Anti-OXA1L antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal OXA1L antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Mitochondrial inner membrane protein OXA1L.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human Mitochondrial inner membrane protein OXA1L.Q15070\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOXA1L also known as mitochondrial inner membrane protein OXA1L functions mechanically in the insertion and assembly of proteins in the mitochondrial inner membrane. This protein with a mass of approximately 45 kDa localizes to the mitochondria and exhibits broad tissue expression. OXA1L plays a role in protein translocation specifically contributing to the insertion of multi-spanning membrane proteins coming from the mitochondrial ribosomes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOXA1L facilitates the integration of proteins into the mitochondrial inner membrane essential for maintaining mitochondrial function and biogenesis. OXA1L operates as part of a larger complex that assists protein assembly and stabilization. Such interactions highlight its role in mitochondrial respiratory chain assembly necessary for maintaining cellular energy balance.\u003cbr\u003e\nPathways\u003cbr\u003e\nOXA1L integrates specifically into the pathway of mitochondrial oxidative phosphorylation. This target works alongside important proteins like COX1 and COX2 shaping the proper assembly of components of the electron transport chain. Additionally OXA1L interacts with the mitochondrial import machinery vital for maintaining the efficiency of protein import pathways that regulate cellular respiration.\u003cbr\u003e\nMutations or dysregulation of OXA1L correlate with mitochondrial disorders and neurological diseases including sensorineural hearing loss and mitochondrial complex I deficiency. NDUFAF2 involved in complex I assembly shows interaction with OXA1L in these conditions highlighting a shared pathway that can lead to disrupted energy production and neurological symptoms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852267475113,"sku":"ab88975","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab88975","provider":"Iright","version":"1.0","type":"link"}