{"product_id":"abcam-ab89135","title":"Abcam, ab89135, Anti-PPP1R16A antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal PPP1R16A antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PPP1R16A.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human PPP1R16A.Q96I34\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe PPP1R16A protein also known as myosin light chain phosphatase target subunit 1 is part of the protein phosphatase 1 regulatory subunits. It weighs approximately 84 kDa and is mainly found in tissues like brain and skeletal muscle. It functions as a regulatory subunit modulating the activity of protein phosphatase 1 (PP1) a critical enzyme in cellular signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein plays a significant role in the regulation of myosin phosphatase activity influencing muscle function. As part of a multi-subunit complex PPP1R16A interacts with PP1 to dephosphorylate myosin light chains which is essential for muscle relaxation. This process ensures proper muscle contraction and relaxation cycles in response to cellular signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nProtein phosphatase activity plays key roles in both the smooth muscle contraction and Rho GTPase signaling pathways. PPP1R16A by regulating myosin light chain phosphorylation status interacts with proteins like Rho-associated coiled-coil containing protein kinase (ROCK) within these pathways. This involvement positions PPP1R16A as a vital player in pathways that govern cell motility and muscle contraction.\u003cbr\u003e\nThe dysregulation of PPP1R16A activity is associated with conditions such as hypertension and asthma. Its interaction with ROCK and misregulation in myosin phosphatase activity can contribute to abnormal muscle contractility playing a role in the pathophysiology of these diseases. Understanding this interaction helps in exploring therapeutic targets for related cardiovascular and respiratory disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852267278505,"sku":"ab89135","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab89135","provider":"Iright","version":"1.0","type":"link"}