{"product_id":"abcam-ab89290","title":"Abcam, ab89290, Anti-TRIM26 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal TRIM26 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TRIM26.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human TRIM26.Q12899\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRIM26 also known as Tripartite Motif Containing 26 is a member of the TRIM protein family characterized by the presence of a RING-finger domain a B-box domain and a coiled-coil region. The protein has an approximate mass of 67 kDa. TRIM26 is expressed in various tissues with substantial presence in immune-related tissues such as the spleen and lymph nodes. It acts as an E3 ubiquitin ligase which facilitates the transfer of ubiquitin to target proteins guiding them to degradation via the proteasome.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRIM26 functions in innate immune signaling and type I interferon production. It associates with other protein complexes that mediate these immune responses. Through its ubiquitin ligase activity TRIM26 influences proteins involved in the cellular antiviral defense. Its activity regulates the stability and function of signaling molecules playing an important part in modulating immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRIM26 participates in the interferon signaling pathway and the NF-kB signaling pathway. In these pathways TRIM26 interacts with proteins such as ubiquitin-specific peptidase 15 (USP15) and tumor necrosis factor receptor-associated factor 6 (TRAF6). These interactions and regulatory activities are important for controlling the expression of inflammatory and antiviral genes integrating TRIM26 within the broader network of immune regulation.\u003cbr\u003e\nTRIM26 has associations with autoimmune diseases and viral infections. Alterations in TRIM26 expression or function may contribute to conditions like systemic lupus erythematosus where immune system regulation is compromised. Furthermore its role in viral defense mechanisms links it to diseases involving chronic viral infections. TRIM26 also interacts with proteins such as stimulator of interferon genes (STING) which is involved in recognizing viral DNA highlighting its significance in disease mechanisms involving immune evasion and chronic inflammation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852269342889,"sku":"ab89290","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab89290","provider":"Iright","version":"1.0","type":"link"}