{"product_id":"abcam-ab9202","title":"Abcam, ab9202, Anti-Dengue Envelope antibody [D1-11(3)]","description":"\u003cp\u003eSize: 250µg\u003cbr\u003e\nMouse Monoclonal POLG antibody. Suitable for I-ELISA, ELISA, Dot, WB and reacts with Dengue virus 1, Dengue virus 2, Dengue virus 3 samples. Cited in 11 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:D1-11(3),\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Dengue virus 1, Dengue virus 2, Dengue virus 3,\u003cbr\u003e\nApplications:I-ELISA, ELISA, WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nSpecificity:This antibody reacts with dengue virus type 1,2, and 3 as determined by blotting assays, ELISA and IF techniques.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe myeloma cell line used as a fusion partner produces small amounts of IgG1, therefore IgG1 is sometimes present in the preparation.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Purification notes-All hybridoma proteins are produced from tissue culture and purified using Protein A- affinity chromatography., Storage buffer-pH: 7.2Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Dengue Virus commonly known as DENV includes four serotypes: DENV-1 DENV-2 DENV-3 and DENV-4. Each serotype comprises a complex structure with a viral envelope containing the structural proteins envelope (E) and membrane (M) among others. The envelope protein is key for entry into host cells by mediating binding and fusion. The non-structural proteins such as NS3 and NS5 are involved in viral replication and assembly. The virus circulates across tropical and subtropical regions primarily transmitted by Aedes aegypti mosquitoes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDengue Virus impacts human cells by initiating a series of interactions once it enters the blood system. It hijacks the host's cellular machinery to replicate and generate viral particles. It triggers immune responses leading to production of antibodies such as anti-Dengue antibodies. The virus does not operate alone but within a complex involving the host immune response influencing cell signaling pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nDengue Virus is integrated into the type I interferon signaling pathway and the TLR3 signaling pathway. These pathways trigger antiviral responses that attempt to limit viral replication. The virus interacts with host proteins including STAT1 and IRF3 which play roles in these pathways. The virus evades the immune response by modifying these pathways enhancing its survival and replication in the host.\u003cbr\u003e\nDengue Virus is connected to Dengue Fever and Dengue Hemorrhagic Fever which can lead to severe complications and even death. It modulates host proteins involving cytokines like TNF-alpha and interleukins contributing to pathogenesis and immune system breakdown. Understanding the virus’s interaction with these proteins is essential in the development of vaccines and therapeutic antibodies targeting Dengue infections.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860489949353,"sku":"ab9202","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab9202","provider":"Iright","version":"1.0","type":"link"}