{"product_id":"abcam-ab92537","title":"Abcam, ab92537, Anti-RIAM antibody [EPR2806]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal RIAM antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 8 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR2806,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRIAM also known as Rap1-GTP-interacting adaptor molecule is a protein involved in intracellular signaling. RIAM has a molecular weight of approximately 76 kDa. It is expressed in various tissues with a significant presence in hematopoietic cells and endothelial cells. This protein plays a part in connecting cell membrane molecules with actin cytoskeleton therefore promoting cellular adhesion.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRIAM is essential for the integrin-mediated adhesion processes. It functions as a critical adaptor forming complexes with talin and other signaling proteins which facilitate the activation of integrins. Through these actions RIAM contributes to cell migration immune responses and platelet aggregation. Its interactions influence cellular adhesion and communication pivotal for maintaining tissue structure and response to injuries.\u003cbr\u003e\nPathways\u003cbr\u003e\nRIAM is a vital component in the signaling pathways involving the small GTPase Rap1 which regulates integrins and their effect on cell adhesion. Particularly RIAM serves as a bridge between Rap1 and talin facilitating integrin activation. This process plays an essential role in the focal adhesion pathway where proteins like Kindlin also collaborate to modulate cellular adhesion and movement impacting various physiological processes.\u003cbr\u003e\nRIAM has connections with immune dysfunction and cardiovascular diseases. For example abnormalities in RIAM-mediated integrin activation can lead to improper immune cell trafficking and related immunodeficiencies. In cardiovascular contexts defective RIAM activity might impair endothelial cell function and contribute to vascular diseases. In these scenarios proteins like talin are closely associated with RIAM often sharing roles in the pathogenesis of these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850265284777,"sku":"ab92537","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab92537","provider":"Iright","version":"1.0","type":"link"}