{"product_id":"abcam-ab92922","title":"Abcam, ab92922, Recombinant Human IFITM2 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human IFITM2 protein is a Human Full Length protein, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, ELISA, WB, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGE, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q01629,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Preservative: 0.68% ImidazoleConstituents: 2.9% Sodium chloride, 0.316% Tris HCl, 0.0078% 2-Mercaptoethanol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe IFITM2 protein also known as Interferon-Induced Transmembrane Protein 2 is a member of the IFITM family which includes IFITM1 and IFITM3. IFITM2 has a molecular mass of approximately 14 kDa. It is found mainly in the plasma membrane and is expressed in various tissues notably immune cells. It functions as part of the cellular response to viral infections acting mechanically to restrict virus entry into the host cell and prevent replication of various viruses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of IFITM2 extends beyond mechanical blocking as it participates in the immune response by inhibiting the fusion of viral membranes with endosomal membranes. IFITM2 operates together with IFITM1 and IFITM3 forming a complex that boosts its antiviral capacity. The protein contributes to the defense mechanism against a broad range of viral pathogens including influenza and dengue viruses.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearch shows that IFITM2 is involved in the interferon signaling pathway which regulates immune response to pathogens. In this pathway IFITM proteins are part of the type I and type II interferon responses enhancing cellular resistance to viral infection. The protein collaborates with others such as STAT1 in maintaining cellular defenses against pathogens.\u003cbr\u003e\nSeveral studies have connected IFITM2 to influenza and other viral infections. Altered function or expression of IFITM2 could relate to increased susceptibility to some viral infections or influence the disease progression. The interacts with proteins such as IFITM3 further implicating its involvement in the clinical outcomes of these viral diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843852882089,"sku":"ab92922","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab92922","provider":"Iright","version":"1.0","type":"link"}