{"product_id":"abcam-ab93610","title":"Abcam, ab93610, Anti-NMDAR2B antibody [S59]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-NMDAR2B antibody [S59] (ab93610) is a mouse monoclonal antibody detecting NMDAR2B in  Western Blot, Flow Cytometry, IP, IHC-P, ICC\/IF . Suitable for  Human, Mouse, Rat . - Recombinant format for unrivalled batch-batch consistency - Over 20 publications - Trusted since 2010\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:S59,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human, Mouse,\u003cbr\u003e\nApplications:IP, IHC-P, Flow Cyt, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Rat Grin2b aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q00960,\u003cbr\u003e\nSpecificity:No cross-reactivity with NMDAR2A.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-NMDAR2B antibody [S59] (ab93610) is a mouse recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of NMDAR2B?\u003cbr\u003e\nAnti-NMDAR2B [S59] (ab93610) specifically detects a band for NMDAR2B (UniProt: Q00960) at a molecular weight of 166kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-NMDAR2B [S59] (ab93610) was first used in a scientific publication in 2010 and has been cited over 20 times in peer-reviewed journals.\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [S59] also available for your convenience: ab93610, PE -\u003cbr\u003e\nab274365\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNMDAR2B also known as NR2B or GluN2B functions as a subunit of the NMDA receptor complex. It plays a role in synaptic transmission and plasticity in the central nervous system. The target weighs approximately 166 kDa. It is highly expressed in the cerebral cortex hippocampus and striatum. NMDAR2B interacts with other subunits in the NMDA receptor which assemble to form a functional ion channel that allows for calcium ion influx when activated by glutamate and glycine.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe NMDAR2B subunit contributes to the regulation of synaptic strength and is essential for processes involved in learning and memory. As part of the NMDA receptor complex it mediates excitatory neurotransmission and is involved in synaptic plasticity processes such as long-term potentiation (LTP). These functions are significant for cognitive function and neural development. The receptor's role in signal transduction is aided by the unique properties conferred by the NMDAR2B subunit such as its high affinity for glycine and slower deactivation kinetics.\u003cbr\u003e\nPathways\u003cbr\u003e\nNMDAR2B is involved in the glutamatergic signaling pathway which is important for neural communication. It also participates in the calcium signaling pathway affecting cellular responses to external stimuli. The protein interacts with CaMKII and PSD-95 which are proteins that influence synaptic strength and architecture through these pathways. Its involvement links it to a variety of signaling events important for brain function.\u003cbr\u003e\nAlterations in NMDAR2B have been associated with neurodegenerative conditions such as Alzheimer's disease and neurodevelopmental disorders like schizophrenia. The protein's malfunction can lead to abnormal synaptic connectivity and excitotoxicity. It is linked to other proteins associated with these diseases such as beta-amyloid in Alzheimer's and dopamine receptor dysregulation in schizophrenia indicating its role in disease progression and symptom manifestation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844277031081,"sku":"ab93610","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab93610","provider":"Iright","version":"1.0","type":"link"}