{"product_id":"abcam-ab94805","title":"Abcam, ab94805, Anti-Respiratory Syncytial Virus M2-1 Protein antibody [RSV5H5]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-Respiratory Syncytial Virus M2-1 Protein antibody [RSV5H5] (ab94805) is a mouse monoclonal antibody detecting Respiratory Syncytial Virus M2-1 Protein in  Western Blot, IP, ICC\/IF, ELISA . Suitable for  Respiratory syncytial virus . - Trusted since 2010\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:RSV5H5,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Respiratory syncytial virus,\u003cbr\u003e\nApplications:IP, ELISA, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody has broad specificity for Respiratory Syncytial Virus of both sub-groups A and B\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Respiratory Syncytial Virus M2-1 Protein antibody [RSV5H5] (ab94805) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry\/immunofluorescence (ICC\/IF), ELISA in Respiratory syncytial virus samples.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-Respiratory Syncytial Virus M2-1 Protein [RSV5H5] (ab94805) was first used in a scientific publication in 2010 and has been cited over 10 times in peer-reviewed journals.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: 99.98% PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Respiratory Syncytial Virus M2-1 protein also known as RSV M2-1 is an essential component in the viral replication process. This protein has a mass of approximately 19 kDa and is primarily expressed in the infected host cells. M2-1 functions as an antiterminator during viral mRNA transcription allowing the virus to produce full-length mRNA transcripts. Its role is critical for the successful synthesis of viral proteins which are necessary for virus assembly and release.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Respiratory Syncytial Virus M2-1 protein interacts with the viral RNA polymerase complex. Its activity prevents premature termination ensuring the proper transcription of viral genes. The protein plays a significant role in the synthesis of viral RNA facilitating the transition from transcription initiation to elongation. M2-1 does not act alone; it forms part of a dynamic complex with other viral proteins such as the RSV L protein and its cofactor the P protein.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe M2-1 protein is important in the replication and transcription pathway of the Respiratory Syncytial Virus. This pathway involves other viral proteins like N (nucleoprotein) and M (matrix protein) which help stabilize and protect the viral RNA aiding in the virus's lifecycle. M2-1 regulates the switch from RNA synthesis to genome replication integrating its mechanistic functions into the larger context of viral propagation and host cell interaction.\u003cbr\u003e\nThe M2-1 protein of the Respiratory Syncytial Virus plays a central role in the pathogenesis of respiratory infections. RSV is a major cause of severe respiratory tract infections particularly in infants and the elderly causing conditions such as bronchiolitis and pneumonia. The M2-1 protein's interaction with the viral L protein during RNA synthesis can be a target for antiviral strategies aimed at disrupting the virus's replication capabilities thereby reducing disease severity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854737133737,"sku":"ab94805","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab94805","provider":"Iright","version":"1.0","type":"link"}