{"product_id":"abcam-ab95940","title":"Abcam, ab95940, Anti-FGFRL1 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal FGFRL1 antibody. Suitable for WB, IHC-P and reacts with Transfected cell lysate, Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FGFRL1 aa 150-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human FGFRL1 aa 150-500. The exact immunogen used to generate this antibody is proprietary information.Q8N441\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFGFRL1 also known as Fibroblast Growth Factor Receptor-Like 1 is a protein with a molecular mass of approximately 120 kDa. This protein structurally resembles other members of the fibroblast growth factor receptors but lacks the intracellular kinase domain that characterizes them. It is expressed mainly in tissues such as the heart kidney and developing skeletal system. FGFRL1 acts mechanically as a receptor binding fibroblast growth factors but differing from its relatives due to its inability to transduce signals through a conventional kinase signaling pathway.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFGFRL1 plays roles in growth and development processes by modulating interactions between cells and the extracellular environment. It does not independently form a signaling complex but modulates the activity of other fibroblast growth factor receptors by acting in a regulatory capacity. FGFRL1 contributes to tissue development and differentiation by influencing cell proliferation migration and apoptosis. This regulation is essential in proper organogenesis especially involving cardiovascular structures and bones.\u003cbr\u003e\nPathways\u003cbr\u003e\nFGFRL1 interacts significantly with fibroblast growth factor signaling and phosphoinositide 3-kinase (PI3K)\/AKT pathways. These pathways govern processes such as cellular growth and survival. FGFRL1 modulates interactions in the fibroblast growth factor pathway with related receptors like FGFR1 to FGFR4 modulating their signal without intrinsic kinase activity. It impacts PI3K\/AKT signaling indirectly by altering receptor availability and potentially affecting downstream pathway cascades.\u003cbr\u003e\nFGFRL1 links to skeletal disorders such as craniosynostosis where premature fusion of skull bones occurs. Mutations or dysregulations in FGFRL1 disrupt normal tissue development causing abnormal bone growth. Additionally FGFRL1 has associations with cardiac malformations due to its role in heart development. Despite its distinctive activity FGFRL1's dysregulation often ties into networks involving FGFR1 to FGFR4 in these pathologies showcasing involvement in broader growth factor signaling disruptions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850145288361,"sku":"ab95940","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab95940","provider":"Iright","version":"1.0","type":"link"}