{"product_id":"abcam-ab96028","title":"Abcam, ab96028, Anti-ST3GAL2 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal ST3GAL2 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ST3GAL2 aa 50-300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ST3GAL2 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.Q16842\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nST3GAL2 also known as ST3 beta-galactoside alpha-23-sialyltransferase 2 is an enzyme encoded by the ST3GAL2 gene. It is involved in the transfer of sialic acid onto galactose-containing oligosaccharides. The protein has a molecular mass of approximately 38 kDa. ST3GAL2 is expressed in a variety of tissues with higher expression reported in the brain and placenta. It localizes mainly to the Golgi apparatus where it participates in the modification of glycoproteins and glycolipids.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme ST3GAL2 contributes to the biosynthesis of sialylated glycoconjugates which are important in cellular communication and stability. It plays a role in producing sialyl Lewis X (sLeX) a ligand involved in cell adhesion. ST3GAL2 operates as part of the Golgi glycosylation machinery and influences the functional properties of cell surface molecules. Its activity impacts processes such as immune response and signaling pathways where the proper display of sialylated structures is required for interacting with selectins.\u003cbr\u003e\nPathways\u003cbr\u003e\nST3GAL2 plays a vital role in the glycosylation and glycan biosynthesis pathways. It impacts the O-glycan biosynthesis pathway where it contributes to the capping of glycan chains with sialic acid. This sialylation process affects the recognition and binding activities of selectins a family of cell adhesion proteins. In particular ST3GAL2 interacts with other enzymes like ST3GAL1 and ST6GAL1 both of which participate in creating complex glycan structures.\u003cbr\u003e\nST3GAL2 associates with cancer and neurological disorders. Altered sialylation patterns driven by overexpression or underexpression of ST3GAL2 can influence tumor progression and metastasis. In cancer changes in glycan structures affect interactions with the immune system and modulate cell migration. Additionally ST3GAL2 connects to disorders involving the immune system as modifications in glycan structures can impact the function of immune-related proteins like selectins influencing inflammatory response and immune escape mechanisms in tumor environments.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850119467177,"sku":"ab96028","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab96028","provider":"Iright","version":"1.0","type":"link"}