{"product_id":"abcam-ab96104","title":"Abcam, ab96104, Anti-PTS\/PTPS antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal PTS\/PTPS antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human 6-pyruvoyl tetrahydrobiopterin synthase aa 1 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human 6-pyruvoyl tetrahydrobiopterin synthase aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q03393\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPTS\/PTPS also known as 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase is an enzyme involved in the biosynthesis of tetrahydrobiopterin (BH4). Its molecular weight is approximately 23 kDa. The enzyme is expressed in various tissues including the liver kidney and brain. The enzyme catalyzes a step in the conversion of 78-dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin which is an important step in the BH4 production pathway.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPTS\/PTPS plays a significant role in neurotransmitter synthesis and regulation. BH4 acts as a cofactor for several hydroxylase enzymes these enzymes include phenylalanine hydroxylase tyrosine hydroxylase and tryptophan hydroxylase. PTS\/PTPS contributes to the production of neurotransmitters like dopamine serotonin and nitric oxide through its role in the biosynthesis of BH4. The protein functions as a part of a complex that includes other biosynthetic enzymes involved in the same pathway.\u003cbr\u003e\nPathways\u003cbr\u003e\nPTS\/PTPS is essential in the pathways involved in neurotransmitter metabolism and amino acid hydroxylation. The enzyme is intimately associated with the phenylalanine tyrosine and tryptophan metabolic pathways. In these pathways it interacts with proteins such as phenylalanine hydroxylase and nitric oxide synthase supporting the conversion of amino acids into critical neurotransmitters and molecules for physiological processes.\u003cbr\u003e\nPTS\/PTPS dysfunction links to neurological conditions and metabolic disorders. Mutations or deficiencies in the enzyme are associated with hyperphenylalaninemia due to BH4 deficiency impacting phenylalanine metabolism and leading to severe neurological symptoms. Another related disorder is dystonia a movement disorder where altered dopamine biosynthesis occurs. The interactions with enzymes like phenylalanine hydroxylase become disrupted further influencing the disease mechanisms and contributing to symptoms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850158461097,"sku":"ab96104","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab96104","provider":"Iright","version":"1.0","type":"link"}