{"product_id":"abcam-ab99328","title":"Abcam, ab99328, Recombinant human FKBP14 protein","description":"\u003cp\u003eSize: 100µg \/ 500µg\u003cbr\u003e\nRecombinant human FKBP14 protein is a Human Full Length protein, in the 20 to 211 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, Mass Spec, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:Specific activity is \u0026gt; 240nmol\/min\/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAPF-pNA per minute at 37°C in Tris-Hcl pH8.0 using chymotrypsin.,\u003cbr\u003e\nAccession:Q9NWM8,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.4Constituents: PBS, 10% Glycerol (glycerin, glycerine)\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFKBP14 also known as FK506-binding protein 14 is a member of the FKBP family of proteins. It acts as a peptidyl-prolyl cis-trans isomerase assisting in the folding of certain proteins by accelerating the interconversion between proline residues. FKBP14 displays a molecular mass of approximately 23 kDa and is expressed in various tissues throughout the body including muscle and connective tissues. The protein typically resides in the endoplasmic reticulum where its main role involves assisting in protein folding processes ensuring proper cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFK506-binding protein 14 impacts protein assembly and stabilization. It participates in the modification and folding of newly synthesized proteins particularly collagens which are essential for maintaining structural integrity in tissues. FKBP14 does not operate as part of a larger complex but plays a significant role in maintaining the stability and functionality of extracellular matrix components. This activity highlights its importance in tissue homeostasis and cellular maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nFKBP14 is integral to collagen biosynthesis and quality control pathways contributing to the structural framework of tissues. It influences the proper secretion and assembly of collagen types interacting with proteins like collagen type I through these processes. These pathways are critical for maintaining the extracellular matrix's structural properties ensuring that tissues correctly support cellular activities and organ architecture.\u003cbr\u003e\nFKBP14 mutations or dysregulation connect to conditions like Bruck syndrome and Ehlers-Danlos syndrome. These diseases involve connective tissue abnormalities where defective collagen processing leads to impaired tissue integrity. Within Bruck syndrome FKBP14 directly relates to incorrect collagen modification which affects structural strength associating with proteins such as lysyl hydroxylase. Studying the interactions and functions of FKBP14 provides insight into these connective tissue disorders' underlying mechanisms and potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843969372329,"sku":"ab99328","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab99328","provider":"Iright","version":"1.0","type":"link"}