{"product_id":"biolegend-102708","title":"Biolegend, 102708, PE anti-mouse CD38 Antibody, 200μg","description":"\u003cp\u003eCD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.\u003cbr\u003e\n200μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse bone marrow pre-B cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Meyer T, et al. 2022. Proc Natl Acad Sci U S A. 119:e2211310119. PubMed Lütge M, et al. 2023. Nat Immunol. . PubMed Borbet TC, et al. 2023. iScience. 26:106810. PubMed Kodali S, et al. 2022. J Immunol. 208:1085. PubMed Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed Vesin B, et al. 2022. Mol Ther. 30:2984. PubMed Roco JA et al. 2019. Immunity. 51(2):337-350 . PubMed Stahnke S, et al. 2021. Current Biology. 31(10):2051-2064.e8. PubMed Lv H, et al. 2020. Cell Metabolism. 33(1):110-127.e5. PubMed Nadafi R, et al. 2020. Cell Reports. 30(12):4110-4123. PubMed Zhang YN, et al. 2020. EBioMedicine. 56:102819. PubMed Roy K, et al. 2019. Immunity. 50:616. PubMed Pradhan K, et al. 2021. Front Immunol. 12:778830. PubMed Chatterjee S et al. 2017. Cell metabolism. 27(1):85-100 . PubMed Wittner J, et al. 2022. Mucosal Immunol. 15:668. PubMed Zhang C, et al. 2021. J Virol. 95:e0079021. PubMed Nasarre P, et al. 2021. Cancers (Basel). 13: . PubMed Haniuda K, et al. 2020. Cell Rep. 33:108333. PubMed Sabouri Z, et al. 2016. Nat Commun. 7:13381. PubMed Velazquez VM, et al. 2017. Mol Ther Methods Clin Dev. 0.277083333. PubMed\u003cbr\u003e\nRRID: AB_312928 (BioLegend Cat. No. 102707) AB_312929 (BioLegend Cat. No. 102708)\u003cbr\u003e\nStructure: ADP-ribosyl hydrolase, 42 kD\u003cbr\u003e\nDistribution: B cells, NK cells, T cell subset, brain, muscle, kidney\u003cbr\u003e\nFunction: Regulation of cellular activation\/proliferation, adhesion, metabolism of cADPR and NAADP\u003cbr\u003e\nLigand\/Receptor: CD31, hyaluronic acid\u003cbr\u003e\nAntigen References: 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Shubinsky G, et al. 1997. Immunity 7:315. 3. Cesano A, et al. 1998. J. Immunol. 160:1106. 4. Cockayne DA, et al. 1998. Blood 92:1324.\u003cbr\u003e\nGene ID: 12494\u003cbr\u003e\nUniProt: View information about CD38 on UniProt.org\u003cbr\u003e\nClone: 90\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T10\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862498529449,"sku":"102708","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-102708","provider":"Iright","version":"1.0","type":"link"}