{"product_id":"biolegend-102712","title":"Biolegend, 102712, APC anti-mouse CD38 Antibody, 100μg","description":"\u003cp\u003eCD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse bone marrow pre-B cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Meyer T, et al. 2022. Proc Natl Acad Sci U S A. 119:e2211310119. PubMed Banerjee K, et al. 2023. Eur J Immunol. 53:e2250161. PubMed Ouchida R, et al. 2012. Proc Natl Acad Sci U S A. 109:e2699. PubMed Vijayan K, et al. 2021. Cell Reports. 36(5):109489. PubMed Hayatsu N et al. 2017. Immunity. 47(2):268-283 . PubMed Pérez‐Mazliah D et al. 2017. EBioMedicine. 24:216-230 . PubMed Xu S, et al. 2012. Blood. 119:767. PubMed Onodera T, et al. 2016. J Immunol. 196: 4172 - 4184. PubMed Wilder BK, et al. 2022. NPJ Vaccines. 7:58. PubMed Schoeler K, et al. 2019. FEBS J. 10.1111\/febs.14934. PubMed Matsumoto K, et al. 2017. PLoS One. 12(6):e0175406. PubMed Chatterjee S et al. 2017. Cell metabolism. 27(1):85-100 . PubMed Cavelier C, et al. 2009. Cancer Res. 69:8652. PubMed Lu X, et al. 2019. Cell Rep. 28:472. PubMed Lazarian G, et al. 2021. Cancer Cell. 39(3):380-393.e8. PubMed Kim H, et al. 2011. Exp Hematol. 39:741. PubMed Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed Li X, et al. 2018. Immunity. 48:530. PubMed Platteel ACM, et al. 2018. Front Immunol. 1.544444444. PubMed Li X, et al. 2021. Front Oncol. 11:703087. PubMed Mesin L, et al. 2020. Cell. 180(1):92-106.e11.. PubMed\u003cbr\u003e\nRRID: AB_312932 (BioLegend Cat. No. 102711) AB_312933 (BioLegend Cat. No. 102712)\u003cbr\u003e\nStructure: ADP-ribosyl hydrolase, 42 kD\u003cbr\u003e\nDistribution: B cells, NK cells, T cell subset, brain, muscle, kidney\u003cbr\u003e\nFunction: Regulation of cellular activation\/proliferation, adhesion, metabolism of cADPR and NAADP\u003cbr\u003e\nLigand\/Receptor: CD31, hyaluronic acid\u003cbr\u003e\nAntigen References: 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Shubinsky G, et al. 1997. Immunity 7:315. 3. Cesano A, et al. 1998. J. Immunol. 160:1106. 4. Cockayne DA, et al. 1998. Blood 92:1324.\u003cbr\u003e\nGene ID: 12494\u003cbr\u003e\nUniProt: View information about CD38 on UniProt.org\u003cbr\u003e\nClone: 90\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T10\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862497743017,"sku":"102712","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-102712","provider":"Iright","version":"1.0","type":"link"}