{"product_id":"biolegend-102716","title":"Biolegend, 102716, Alexa Fluor® 647 anti-mouse CD38 Antibody, 100μg","description":"\u003cp\u003eCD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse bone marrow pre-B cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality testedIHC-F - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. For immunohistochemistry on frozen tissue sections, a concentration range of 2.5 - 10 µg\/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Yazicioglu YF, et al. 2023. Nat Immunol. 24:991. PubMed Enterina JR, et al. 2022. Cell Rep. 38:110512. PubMed Gon Y, et al. 2023. PLoS One. 18:e0279389. PubMed Rodda LB et al. 2018. Immunity. 48(5):1014-1028 . PubMed Tan AHY, et al. 2019. Front Immunol. 10:1351. PubMed Nabar NR, et al. 2022. Autophagy. 18:204. PubMed Ray A, et al. 2015. PLoS One. 10: 0137314. PubMed Zhang Y, et al. 2018. J Exp Med. 215:1227. PubMed Lindhorst A, et al. 2021. Cell Death Dis. 12:579. PubMed Hong JP, et al. 2020. Cell Reports Medicine. 1(3):100035. PubMed\u003cbr\u003e\nRRID: AB_2073334 (BioLegend Cat. No. 102716)\u003cbr\u003e\nStructure: ADP-ribosyl hydrolase, 42 kD\u003cbr\u003e\nDistribution: B cells, NK cells, T cell subset, brain, muscle, kidney\u003cbr\u003e\nFunction: Regulation of cellular activation\/proliferation, adhesion, metabolism of cADPR and NAADP\u003cbr\u003e\nLigand\/Receptor: CD31, hyaluronic acid\u003cbr\u003e\nAntigen References: 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Shubinsky G, et al. 1997. Immunity 7:315. 3. Cesano A, et al. 1998. J. Immunol. 160:1106. 4. Cockayne DA, et al. 1998. Blood 92:1324.\u003cbr\u003e\nGene ID: 12494\u003cbr\u003e\nUniProt: View information about CD38 on UniProt.org\u003cbr\u003e\nClone: 90\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T10\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862498365609,"sku":"102716","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-102716","provider":"Iright","version":"1.0","type":"link"}