{"product_id":"biolegend-106105","title":"Biolegend, 106105, PE anti-mouse CD137 Antibody, 50μg","description":"\u003cp\u003eCD137 is a 39 kD TNF-receptor superfamily member also known as 4-1BB, TNFRSF9, Ly-63, and ILA (Induced by Lymphocyte Activation). CD137 is expressed as monomers, dimers, and tetramers on activated T and B cells. Interaction of CD137 with its ligand, 4-1BBL (CD137L), is important in T-B cell costimulation. The 17B5 antibody has been reported to block 4-1BBL costimulated T cell proliferation.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Syrian Hamster\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: in vitro blocking of 4-1BB-mediated T cell proliferation2. The LEAF™ purified antibody (Endotoxin \u0026lt;0.1 EU\/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 106108).\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Lee SW, et al. 2005. J. Immunol. 174:6803. (FC) Zheng G, et al. 2004. J. Immunol. 173:2428. (Block) Zheng H and G. G. Meadows 2005. J. Leukocyte Biol. 78:1070. (FC) PubMed Nishimoto H, et al. 2005. Blood 106:4241. (FC) del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed\u003cbr\u003e\nProduct Citations: Wu R, et al. 2022. Nat Immunol. 23:1536. PubMed Mulder R, et al. 2017. Front Immunol. 1.464583333. PubMed Shitaoka K, et al. 2018. Cancer Immunol Res. 6:378. PubMed Dúcka M, et al. 2021. Neoplasia. 23:326. PubMed Cannons JL, et al. 2021. Cell Rep. 37:109804. PubMed Toomer G, et al. 2022. Viruses. 14:. PubMed Ma C, et al. 2018. Science. 360:eaan5931. PubMed Marangoni F, et al. 2021. Cell. . PubMed Etxeberria I, et al. 2020. Cancer Cell. 36(6):613-629. PubMed Meadows H 2005. J Leukoc Biol. 78:1070. PubMed Marcus A et al. 2018. Immunity. 49(4):754-763 . PubMed Shen M, et al. 2022. Nat Cancer. 3:60. PubMed Pérez-Guijarro E, et al. 2020. Nat Med. 26:781. PubMed Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed Németh T, et al. 2014. Fungal Genet Biol. 65:48. PubMed Kim SI, et al. 2020. Molecular Cancer Therapeutics. 20(1):173-182. PubMed\u003cbr\u003e\nRRID: AB_2205693 (BioLegend Cat. No. 106105) AB_2287565 (BioLegend Cat. No. 106106)\u003cbr\u003e\nDisclaimer: This product may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.\u003cbr\u003e\nStructure: TNF-R superfamily, 39 kD\u003cbr\u003e\nDistribution: Activated T cells and B cells\u003cbr\u003e\nFunction: T-B cell costimulation\u003cbr\u003e\nLigand\/Receptor: 4-1BB ligand (CDw137L)\u003cbr\u003e\nCell Type: B cells, T cells, Tregs\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Alderson MR, et al. 1994. Eur. J. Immunol. 24:2219. 3. Schwarz H, et al. 1996. Blood 87:2839.\u003cbr\u003e\nGene ID: 21942\u003cbr\u003e\nUniProt: View information about CD137 on UniProt.org\u003cbr\u003e\nClone: 17B5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: 4-1BB, TNFRSF9, Ly-63, ILA (Induced by Lymphocyte Activation), CD137\u003cbr\u003e\nIsotype: Syrian Hamster IgG\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860826575017,"sku":"106105","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-106105","provider":"Iright","version":"1.0","type":"link"}