{"product_id":"biolegend-106123","title":"Biolegend, 106123, PE\/Cyanine5 anti-mouse CD137 Antibody, 25μg","description":"\u003cp\u003eCD137 is a 39 kD TNF-receptor superfamily member also known as 4-1BB, TNFRSF9, Ly-63, and ILA (Induced by Lymphocyte Activation). CD137 is expressed as monomers, dimers, and tetramers on activated T and B cells. Interaction of CD137 with its ligand, 4-1BBL (CD137L), is important in T-B cell costimulation. The 17B5 antibody has been reported to block 4-1BBL costimulated T cell proliferation.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Syrian Hamster\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine5 under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: in vitro blocking of 4-1BB-mediated T cell proliferation2. The LEAF™ purified antibody (Endotoxin \u0026lt;0.1 EU\/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 106108).\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Lee SW, et al. 2005. J. Immunol. 174:6803. (FC) Zheng G, et al. 2004. J. Immunol. 173:2428. (Block) Zheng H and G. G. Meadows 2005. J. Leukocyte Biol. 78:1070. (FC) PubMed Nishimoto H, et al. 2005. Blood 106:4241. (FC) del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed\u003cbr\u003e\nRRID: AB_3674967 (BioLegend Cat. No. 106123) AB_3674967 (BioLegend Cat. No. 106124)\u003cbr\u003e\nStructure: TNF-R superfamily, 39 kD\u003cbr\u003e\nDistribution: Activated T cells and B cells\u003cbr\u003e\nFunction: T-B cell costimulation\u003cbr\u003e\nLigand\/Receptor: 4-1BB ligand (CDw137L)\u003cbr\u003e\nCell Type: B cells, T cells, Tregs\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Alderson MR, et al. 1994. Eur. J. Immunol. 24:2219. 3. Schwarz H, et al. 1996. Blood 87:2839.\u003cbr\u003e\nGene ID: 21942\u003cbr\u003e\nUniProt: View information about CD137 on UniProt.org\u003cbr\u003e\nClone: 17B5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: 4-1BB, TNFRSF9, Ly-63, ILA (Induced by Lymphocyte Activation), CD137\u003cbr\u003e\nIsotype: Syrian Hamster IgG\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860826706089,"sku":"106123","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-106123","provider":"Iright","version":"1.0","type":"link"}