{"product_id":"biolegend-111803","title":"Biolegend, 111803, PE anti-mouse CD163 Recombinant Antibody, 25μg","description":"\u003cp\u003eCD163, also known as GHI\/61, M130, RM3\/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen, is a member of the group B scavenger receptor cysteine-rich superfamily. It is a 134 kD (non-reduced)\/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem\/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammatory diseases.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2936729 (BioLegend Cat. No. 111803) AB_2936729 (BioLegend Cat. No. 111804)\u003cbr\u003e\nStructure: Type 1 transmembrane glycoprotein, 134 kD (non-reduced)\/155 kD (reduced) glycoprotein\u003cbr\u003e\nDistribution: Macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem\/progenitor cells\u003cbr\u003e\nFunction: Binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages\u003cbr\u003e\nCell Type: Dendritic cells, Hematopoietic stem and progenitors, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Jiang L, et al. 2020. Cell. 183:1219-1233.e18. Harb H, et al. 2021. Immunity. 54:1186-1199.e7.\u003cbr\u003e\nGene ID: 93671\u003cbr\u003e\nUniProt: View information about CD163 on UniProt.org\u003cbr\u003e\nClone: QA20A94\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: M130, MM130, SCARI1\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866194497705,"sku":"111803","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-111803","provider":"Iright","version":"1.0","type":"link"}