{"product_id":"biolegend-121707","title":"Biolegend, 121707, Alexa Fluor® 647 anti-mouse Qa-2 Antibody, 25μg","description":"\u003cp\u003eMouse Qa-2 is a 40 kD GPI-linked surface protein. It is a member of nonclassical MHC class Ib molecule encoded by Q5, Q6, Q7, Q9, and Q10 genes of the H-2 complex. Qa-2 is a nonpolymorphic molecule primarily expressed on mouse T and B cells. The expression level of Qa-2 on mature T cells is higher than on B cells. Different mouse strains express Qa-2 at varying levels. Qa-2, in association with β2-microglobulin, binds to peptide and plays a role in antigen presentation.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: C3H.SW mouse skin graft and splenocytes\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation2.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Sharrow SO, et al. 1989. J. Immunol. 142:3495. Patk E, et al. 1993. Microbiol. Immunol. 37:743.\u003cbr\u003e\nProduct Citations: Kasinath V, et al. 2019. Kidney Int. 310:95. PubMed Dong J, et al. 2013. PLoS One. 8:e56378. PubMed Tang H, et al. 2016. Sci Rep. 6:30448. PubMed Andersen L, et al. 2020. Cell Reports. 29(13):4447-4459.e6.. PubMed\u003cbr\u003e\nRRID: AB_571988 (BioLegend Cat. No. 121707) AB_571989 (BioLegend Cat. No. 121708)\u003cbr\u003e\nStructure: GPI-linked protein, associates with β2-microglobulin, 40 kD\u003cbr\u003e\nDistribution: T and B cells, mature T cells expression higher than B cells\u003cbr\u003e\nFunction: Antigen presentation, promote immune response\u003cbr\u003e\nLigand\/Receptor: Peptide\u003cbr\u003e\nCell Type: B cells, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: MHC Antigens\u003cbr\u003e\nAntigen References: 1. Sharrow SO, et al. 1989. J. Immunol. 142:3495. 2. Mann DW, et al. 1987. J. Immunol. 138:240. 3. Mellor AL, et al.1985. Proc. Natl. Acad. Sci.USA. 82:5920. 4. Tabaczewski P, et al. 1997. J. Immunol. 159:2771. 5. Chiang EY and Stroynowski I. 2005. J. Immunol. 174:5367.\u003cbr\u003e\nGene ID: 111458\u003cbr\u003e\nUniProt: View information about Qa-2 on UniProt.org\u003cbr\u003e\nClone: 695H1-9-9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Nonclassical MHC-Ib, H2-Qa2\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862470316201,"sku":"121707","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-121707","provider":"Iright","version":"1.0","type":"link"}