{"product_id":"biolegend-123608","title":"Biolegend, 123608, Alexa Fluor® 647 anti-mouse CD104 Antibody, 100μg","description":"\u003cp\u003eCD104 is a 205 kD type I transmembrane glycoprotein, also known as integrin β4 chain or β4 integrin, that associates with integrin α6 (CD49f) to form the α6\/β4 (CD49f\/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells, and a subset of pre-T cells. The CD49f\/CD104 heterodimer is an adhesion receptor for laminins (especially laminin 5) and keratin filaments, and is involved in the regulation of hemidesmosome formation and cell proliferation and activation.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Tumor-associated antigen TSP-180 from BALB\/c lung carcinoma\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported (for the relevant formats) applications include: immunohistochemical staining1.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Tennenbaum T, et al. 1993. Cancer Res. 53:4803. (IHC)\u003cbr\u003e\nProduct Citations: Weiner AI 2022. Cell Reports. 41(11):111805. PubMed Cassandras M, et al. 2020. Nat Cell Biol. 1295:22. PubMed Guo L, et al. 2019. Mol Cell. 73:815. PubMed Hara T, et al. 2022. Cell Mol Gastroenterol Hepatol. 13:1449. PubMed\u003cbr\u003e\nRRID: AB_2563511 (BioLegend Cat. No. 123607) AB_2563512 (BioLegend Cat. No. 123608)\u003cbr\u003e\nStructure: Integrin β chain, 205 kD, forms heterodimer with integrin α6 (CD49f)\u003cbr\u003e\nDistribution: Epithelial cells, endothelial cells, some tumor cells, pre-T cell subset\u003cbr\u003e\nFunction: Adhesion\u003cbr\u003e\nLigand\/Receptor: Laminins, keratin filaments\u003cbr\u003e\nCell Type: Embryonic Stem Cells, Endothelial cells, Epithelial cells, T cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Stem Cells\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Kennel SJ, et al. 1992. J. Cell Sciences 101:1992.\u003cbr\u003e\nGene ID: 192897\u003cbr\u003e\nUniProt: View information about CD104 on UniProt.org\u003cbr\u003e\nClone: 346-11A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Integrin β4, β4 integrin, TSP-1180, ITGB4\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862377320617,"sku":"123608","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-123608","provider":"Iright","version":"1.0","type":"link"}