{"product_id":"biolegend-138605","title":"Biolegend, 138605, FITC anti-mouse Ly-6D Antibody, 25μg","description":"\u003cp\u003eLymphocyte antigen 6D (Ly-6D), also known as thymocyte B-cell antigen (ThB), is a 16 kD GPI-linked cell surface glycoprotein. It belongs to the Ly6 gene family and contains one urokinase receptor (uPAR) \/Ly6 domain. Ly-6D is involved in cell-cell adhesion and signal transduction. Ly-6D marks the earliest stage of B cell lineage commitment from the common lymphoid progenitors (CLP). It is expressed on B cells, immature thymocytes, and plasmacytoid dendritic cells.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: BALB\/c mouse plasmacytoma MOPC-104E\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Eckhardt LA and Herzenberg LA. 1980. Immunogenetics 11:275. (FC)\u003cbr\u003e\nProduct Citations: Haensel D, et al. 2023. Nat Commun. 14:2685. PubMed Haensel D, et al. 2022. Nat Commun. 13:7520. PubMed Weiner AI 2022. Cell Reports. 41(11):111805. PubMed Kurkewich J, et al. 2016. PLoS One. 11: 0161468. PubMed Janela B, et al. 2019. Immunity. 50:1069. PubMed Philip E Boulais et al. 2018. Immunity. 49(4):627-639 . PubMed\u003cbr\u003e\nRRID: AB_11203901 (BioLegend Cat. No. 138605) AB_11203888 (BioLegend Cat. No. 138606)\u003cbr\u003e\nStructure: GPI-linked cell-surface glycoprotein, molecular weight 16 kD, belongs to the Ly6 gene family, contains one urokinase receptor (uPAR) \/Ly6 domain\u003cbr\u003e\nDistribution: B cells, B cell-biased lymphoid progenitor (BLP), thymocytes, plasmacytoid dendritic cells\u003cbr\u003e\nFunction: Cell-cell adhesion and signal transduction\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Thymocytes\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Signal Transduction\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: 1. Inlay MA, et al. 2009. Genes Dev. 23:2376. 2. Gumley TP, et al. 1995. Immunol. Cell Biol. 73:277. 3. Mansson R, et al. 2010. Blood 115:2601. 4. Reese JT, et al. 2001. Dev. Immunol. 8:107.\u003cbr\u003e\nGene ID: 17068\u003cbr\u003e\nUniProt: View information about Ly-6D on UniProt.org\u003cbr\u003e\nClone: 49-H4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Lymphocyte antigen 6D, Thymocyte B-cell antigen, ThB\u003cbr\u003e\nIsotype: Rat IgG2c, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862406844585,"sku":"138605","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-138605","provider":"Iright","version":"1.0","type":"link"}