{"product_id":"biolegend-139203","title":"Biolegend, 139203, PE anti-mouse PDC-TREM Antibody, 25μg","description":"\u003cp\u003ePDC-TREM, also known as plasmacytoid dendritic cell (PDC) -specific receptor, is a member of the TREM receptor family. It is a transmembrane protein composed of an extracellular region with one V-type Ig domain, a transmembrane region with a lysine residue, and a cytoplasmic domain with no recognized signaling motifs. The lysine present in the transmembrane region allows PDC-TREM to form a complex with DAP12 and Plexin-A1. PI3K and Erk 1\/2 are involved in the signal transduction of this complex. PDC-TREM is expressed in TLR-activated PDCs and is involved in the production of IFN-α.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant soluble PDC-TREM\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: Western blot1.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Watarai H, et al. 2008. Proc. Natl. Acad. Sci. USA 105:2993. (WB)Rahim MM, et al. 2013. J. Immunol. 190:3994. PubMed.\u003cbr\u003e\nProduct Citations: Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed Naing A et al. 2019. Cell reports. 26(5):1242-1257 . PubMed Rahim M, et al. 2013. J Immunol. 190:3994. PubMed\u003cbr\u003e\nRRID: AB_10613646 (BioLegend Cat. No. 139203) AB_10613471 (BioLegend Cat. No. 139204)\u003cbr\u003e\nStructure: Member of the TREM receptor family. Type I protein composed of an extracellular region with a single V-type Ig domain, a transmembrane domain with a lysine residue and a cytoplasmic domain with no recognized signaling motifs.\u003cbr\u003e\nDistribution: Expressed on TLR activated plasmacytoid dendritic cells (PDC)\u003cbr\u003e\nFunction: Signal transduction, induces the production of IFN-α\u003cbr\u003e\nInteraction: DAP12, Plexin-A1, PI3K, Erk 1\/2\u003cbr\u003e\nCell Type: Dendritic cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Signal Transduction\u003cbr\u003e\nMolecular Family: Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: 1. Jill W, et al. 2009. Curr. Opin. Immunol. 21:38. 2. Lanier LL. 2009. Immunol. Rev. 227:150.\u003cbr\u003e\nGene ID: 328830\u003cbr\u003e\nUniProt: View information about PDC-TREM on UniProt.org\u003cbr\u003e\nClone: 4A6\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Plasmacytoid dendritic cell-specific receptor\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862407434409,"sku":"139203","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-139203","provider":"Iright","version":"1.0","type":"link"}