{"product_id":"biolegend-142108","title":"Biolegend, 142108, PE\/Cyanine7 anti-mouse TIGIT (Vstm3) Antibody, 100μg","description":"\u003cp\u003eT cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as V-set and transmembrane domain-containing protein 3 (Vstm3), is a 26 kD, type I transmembrane protein and member of the CD28 family. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. Its binding partners include CD155 (PVR) and CD112 (PVRL2). TIGIT is a negative regulator of NK and T cell activation. Engagement of TIGIT by dendritic cells results in their differentiation into a tolerogenic phenotype, with an increased secretion of IL-10 and a diminished production of IL-12. Mice deficient for TIGIT are more susceptible to autoimmune disease.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Joller N, et al. 2010. J. Immunol. 186:1338.\u003cbr\u003e\nProduct Citations: Lin C, et al. 2020. Cancer Immunol Res. 632:8. PubMed Bertrand F, et al. 2017. Nat Commun. 8:2256. PubMed Weulersse M, et al. 2020. Immunity. 53(4):824-839.e10. PubMed Zhao H, et al. 2021. Int J Nanomedicine. 16:4913. PubMed De Ponte Conti B, et al. 2021. Elife. 10:. PubMed Xiao S, et al. 2020. Cell Reports. 32(2):107892. PubMed Tian M, et al. 2021. Elife. 10:. PubMed Zhao H, et al. 2022. Int J Biol Sci. 18:154. PubMed Srivastava S, et al. 2020. Cancer Cell. 39(2):193-208.e10. PubMed Barsoumian HB, et al. 2022. Cancers (Basel). 14:. PubMed\u003cbr\u003e\nRRID: AB_2565648 (BioLegend Cat. No. 142107) AB_2565649 (BioLegend Cat. No. 142108)\u003cbr\u003e\nStructure: Type I transmembrane protein, 26 kD, member of the CD28 family. Contains 1 Ig-like domain and 1 cytoplasmic ITIM motif.\u003cbr\u003e\nDistribution: Activated T cells, follicular T helper cells, NK, memory T cells, Tregs.\u003cbr\u003e\nFunction: Negative regulator of T cell activation and proliferation. Induction of tolerogenic dendritic cells.\u003cbr\u003e\nLigand\/Receptor: CD155 (PVR) and CD112 (PVRL2).\u003cbr\u003e\nCell Type: Dendritic cells, NK cells, T cells, Tregs\u003cbr\u003e\nBiology Area: Immunology, Inhibitory Molecules\u003cbr\u003e\nMolecular Family: Adhesion Molecules, Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: 1. Levin SD, et al. 2011. Eur. J. Immunol. 41:902. 2. Yu X, et al. 2009. Nat. Immunol. 10:48. 3. Stanietsky N, et al. 2009. P. Natl. Acad. Sci. USA 106:17858.\u003cbr\u003e\nGene ID: 100043314\u003cbr\u003e\nUniProt: View information about TIGIT on UniProt.org\u003cbr\u003e\nClone: 1G9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: VSIG9\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860860686505,"sku":"142108","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-142108","provider":"Iright","version":"1.0","type":"link"}