{"product_id":"biolegend-142808","title":"Biolegend, 142808, APC anti-mouse CD159a (NKG2A, 200μg","description":"\u003cp\u003eCD159a, also known as NKG2A or KLRC1 (killer cell lectin-like receptor subfamily C, member 1), is a 43 kD type II transmembrane protein with extracellular C-type lectin domains.  It belongs to the killer cell lectin-like receptor family also known as the NKG2 family.  It is expressed on NK and NKT cells and activated CD8+ T cells.  NKG2A binds to non-classical MHC class I molecule Qa-1 and causes inhibition of NK cell-mediated target-cell lysis.\u003cbr\u003e\n200μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: C57BL\/6 mouse CD94\/NKG2A transfected CHO cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: This product may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use licenses cannot be guaranteed from the University of California.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): McMahon CW, et al. 2002. J. Immunol. 169:1444. (FC) Vance RE, et al. 2002. P. Natl. Acad. Sci. USA 99:868. (FC)\u003cbr\u003e\nProduct Citations: Aghayev T, et al. 2022. Cancer Discov. 12:1960. PubMed Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed Shreeve N, et al. 2021. Immunity. 54(6):1231-1244.e4. PubMed\u003cbr\u003e\nRRID: AB_11125166 (BioLegend Cat. No. 142807) AB_11124538 (BioLegend Cat. No. 142808)\u003cbr\u003e\nStructure: Type II transmembrane protein with extracelluar C-type lectin domains, complexed with CD94; 43 kD\u003cbr\u003e\nDistribution: NK cells and NK T cells from C57BL\/6 mouse\u003cbr\u003e\nFunction: Inhibitory activity via ITIMs\u003cbr\u003e\nLigand\/Receptor: Non-classical MHC-I molecule Qa-1\u003cbr\u003e\nCell Type: Embryonic Stem Cells, Mesenchymal Stem Cells, NK cells, NKT cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Signal Transduction, Stem Cells\u003cbr\u003e\nMolecular Family: CD Molecules, MHC Antigens\u003cbr\u003e\nAntigen References: 1. Vance RE, et al. 1998. J Exp Med. 188:1841-8. 2. Lohwasser S, et al. 1999. Eur J Immunol. 29:755-61. 3. Sivakumar PV, et al. 1999. J Immunol. 162:6976-80. 4. Silver ET, et al. 1999. Immunogenetics 49:727-30. 5. Vance RE, et al. 1999. J Exp Med. 190:1801-12.\u003cbr\u003e\nGene ID: 16641\u003cbr\u003e\nUniProt: View information about CD159a on UniProt.org\u003cbr\u003e\nClone: 16A11\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: KLRC1, NKG2B, NKG2AB6\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860819464361,"sku":"142808","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-142808","provider":"Iright","version":"1.0","type":"link"}