{"product_id":"biolegend-144205","title":"Biolegend, 144205, APC anti-mouse\/human CD207 (Langerin) Antibody, 25μg","description":"\u003cp\u003eCD207, also known as langerin, is a 40 kD single-pass type II transmembrane protein, member of the C-type lectin family. CD207 is expressed on the cell surface and Birbeck granules (BGs) of Langerhans cells, and subsets of thymic and splenic dendritic cells. Its ligands are mannose, n -acetylglucosamine, fucose, and sulfated glycans. Langerin is involved in the antigen processing pathway through capture and internalization of its ligands.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse, Human\u003cbr\u003e\nReported Reactivity: Cynomolgus, Rabbit, Pig\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Langerin extracellular domain-Fc fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Qiu Z, et al. 2022. J Exp Med. 219:. PubMed Kawasaki T, et al. 2022. Cell Rep. 41:111828. PubMed Wong E, et al. 2019. Cell Rep. 29:3047. PubMed Samarchith P Kurup et al. 2019. Cell host \u0026amp; microbe. 25(4):565-577 . PubMed Hartwig T et al. 2018. Cell reports. 25(13):3564-3572 . PubMed Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed Stotesbury C, et al. 2020. Aging Cell. 19:e13170. PubMed Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed\u003cbr\u003e\nRRID: AB_2561997 (BioLegend Cat. No. 144205) AB_2561998 (BioLegend Cat. No. 144206)\u003cbr\u003e\nStructure: Single-pass type II transmembrane protein, 40 kD, one C-type lectin domain, homotrimer\u003cbr\u003e\nDistribution: Langerhans cells, subsets of thymic and splenic dendritic cells\u003cbr\u003e\nFunction: Antigen uptake, antigen processing\u003cbr\u003e\nLigand\/Receptor: Mannose, n-acetylglucosamine, fucose, sulfated glycans\u003cbr\u003e\nCell Type: Dendritic cells, Langerhans cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Romani N, et al. 2012. Curr. Top. Microbiol. Immunol. 351:113. 2. Kaplan DH. 2010. Trends Immunol. 31:446. 3. Clausen BE and Kel JM. 2010. Immunol. Cell. Biol. 88:351. 4. Merad M, et al. 2008. Nat. Rev. Immunol. 8:935.\u003cbr\u003e\nGene ID: 24627850489\u003cbr\u003e\nUniProt: View information about CD207 on UniProt.org\u003cbr\u003e\nClone: 4C7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CLEC4K\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862413463721,"sku":"144205","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-144205","provider":"Iright","version":"1.0","type":"link"}