{"product_id":"biolegend-144802","title":"Biolegend, 144802, Purified anti-mouse CD124 (IL-4Rα) Antibody, 100μg","description":"\u003cp\u003eCD124, a subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common γ-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13.  A truncated form of IL-4Rα exists in soluble form in biological fluids. CD124 is expressed on mouse late precursors and mature B cells, T cells, monocytes, and has low expression on granulocytes.  In B cells, CD124 can bind IL-4 and IL-13 and regulate IgE antibody production. In T cells, the type I IL-4R (IL-4R\/gC) is mostly responsible for Th2 cell expansion by mediating IL-4-dependent activation of the transcription factors in hematopoietic cells. The type II IL-4R (IL-4R\/IL-13Ra1) is the main route for nonhematopoietic cell responses to IL-4 or IL-13.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant Mouse IL4Rα encoding the extracellular domain (amino acid residues 26 - 233) was fused to the carboxy-terminal Fc region of human IgG1 via a linker peptide.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed Gubin MM, et al. 2018. Cell. 175:1014. PubMed Maier B, et al. 2020. Nature. 580:257. PubMed\u003cbr\u003e\nRRID: AB_2561554 (BioLegend Cat. No. 144801) AB_2561555 (BioLegend Cat. No. 144802)\u003cbr\u003e\nStructure: 140 kD type I transmembrane glycoprotein, associates with common γ chain or IL-13 receptor alpha-1 subunit\u003cbr\u003e\nDistribution: B cells, T cells, monocytes, and low levels on granulocytes.\u003cbr\u003e\nFunction: Regulates IgE antibody production in B cells, Th2 cell expansion, and IL-4 or IL-13 induced response in non-hematopoietic cells\u003cbr\u003e\nInteraction: STAT6\u003cbr\u003e\nLigand\/Receptor: IL-4, IL-13\u003cbr\u003e\nCell Type: B cells, Granulocytes, Monocytes, T cells\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Immunology, Signal Transduction, Transcription Factors\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Kashiwada M, et al. 2001. J. Immunol. 167:6382. 2. Gilmour J, et al. 2008. J. Immunol. 124:437. 3. Hage T, et al. 1999. Cell 97:271.\u003cbr\u003e\nGene ID: 16190\u003cbr\u003e\nUniProt: View information about CD124 on UniProt.org\u003cbr\u003e\nClone: I015F8\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-4R\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866105499817,"sku":"144802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-144802","provider":"Iright","version":"1.0","type":"link"}