{"product_id":"biolegend-146305","title":"Biolegend, 146305, PE anti-mouse IL-17RB Antibody, 25μg","description":"\u003cp\u003eIL-17RB, also known as IL17RH1, belongs to the cytokine receptor family.  IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R.  It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells.  It binds IL-17B and IL-17E (IL-25) but not IL-17A or C.  Its interaction with IL-25 has a higher affinity than that with IL-17B.  Binding of IL-17RB and IL-25\/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1.  IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse IL-17RB - Fc chimera (human IgG1)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Wiesner DL, et al. 2015. PLoS Pathog. 11:1004701. PubMed\u003cbr\u003e\nProduct Citations: Wiesner D, et al. 2015. PLoS Pathog. 11:1004701. PubMed Matsubara K, et al. 2016. Hypertens Res. 10.1038\/hr.2015.160. PubMed Zeis P, et al. 2020. Immunity. 53:775. PubMed Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed\u003cbr\u003e\nRRID: AB_2564511 (BioLegend Cat. No. 146305) AB_2564512 (BioLegend Cat. No. 146306)\u003cbr\u003e\nStructure: Single pass type I transmembrane protein, 55.9 kD\u003cbr\u003e\nDistribution: iNKT cells, innate lymphoid cells, Th2 cells\u003cbr\u003e\nFunction: Binds IL-25 with higher affinity than IL-17B, can block IL-25 mediated pathology\u003cbr\u003e\nInteraction: TRAF6 and Act1\u003cbr\u003e\nLigand\/Receptor: IL-25\/IL-17E\u003cbr\u003e\nCell Type: NKT cells, Th2\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Hwang SY, et al. 2004. Arthritis Res. Ther. 6:R120. 2. Rickel EA, et al. 2008. J. Immunol. 181:4299. 3. Terashima A, et al. 2008. J. Exp. Med. 205:2727.\u003cbr\u003e\nGene ID: 50905\u003cbr\u003e\nUniProt: View information about IL-17RB on UniProt.org\u003cbr\u003e\nClone: 9B10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Evi27, IL-17ER, IL17RH1, IL17br, IL-17 receptor B\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862502985897,"sku":"146305","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-146305","provider":"Iright","version":"1.0","type":"link"}