{"product_id":"biolegend-150610","title":"Biolegend, 150610, PE anti-mouse CD192 (CCR2) Antibody, 100μg","description":"\u003cp\u003eCD192, also known as CCR2, is a 42 kD G-protein coupled receptor that is associated with bone marrow homeostasis. Specifically, CD192 mediates monocyte chemotaxis and acts as a receptor for monocyte chemoattractant protein 1 (MCP-1). CD192 is primarily expressed on monocytes and macrophages, with some expression on basophils. It is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis and cancer.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CCR2 transfectants.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Fukuzaki Y, et al. 2023. iScience. 26:106340. PubMed Fang C, et al. 2022. J Pathol. 256:310. PubMed Shanaki-Bavarsad M, et al. 2022. Exp Neurobiol. 31:173. PubMed Greferath U, et al. 2021. Front Cell Neurosci. 14:553708. PubMed Jeljeli M, et al. 2020. Cell Rep. 33:108325. PubMed Samarchith P Kurup et al. 2019. Cell host \u0026amp; microbe. 25(4):565-577 . PubMed Aldrich AL, et al. 2021. The Journal of Immunology. 206(4):751-765. PubMed Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed Li F, et al. 2019. Cancer Res. 79(15). PubMed Leylek R, et al. 2019. Cell Rep. 29:3736. PubMed Galle-Treger L, et al. 2020. J Allergy Clin Immunol. 145:502. PubMed Ben-Yehuda H, et al. 2021. Mol Neurodegener. 16:39. PubMed Laban H, et al. 2018. J Cell Biol. 217:1503. PubMed Nasser H, et al. 2020. Cell Death Discov. 0.29375. PubMed Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed Schnoegl D, et al. 2022. Front Immunol. 13:909270. PubMed Bae S, et al. 2021. Cell Reports. 35(11):109264. PubMed Di Liberto G et al. 2018. Cell. 175(2):458-471 . PubMed\u003cbr\u003e\nRRID: AB_2616981 (BioLegend Cat. No. 150609) AB_2616982 (BioLegend Cat. No. 150610)\u003cbr\u003e\nStructure: G-protein-coupled receptor, 7-transmembrane protein, 42 kD.\u003cbr\u003e\nDistribution: Monocytes\/macrophages and basophils.\u003cbr\u003e\nFunction: Mediator of monocyte chemotaxis and bone marrow homeostasis.\u003cbr\u003e\nLigand\/Receptor: MCP-1, Ccl2, Ccl7, and Ccl13.\u003cbr\u003e\nCell Type: Basophils, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Mack M, et al. 2001. J. Immunol. 166:4697. 2. Dutta P, et al. 2015. Cell Stem Cell. 16:477. 3. Li L, et al. 2008. Kidney Int. 74:1526.\u003cbr\u003e\nGene ID: 12772\u003cbr\u003e\nUniProt: View information about CD192 on UniProt.org\u003cbr\u003e\nClone: SA203G11\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Ccr2, Ckr2, Ccr2a, Ccr2b\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866284052649,"sku":"150610","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-150610","provider":"Iright","version":"1.0","type":"link"}