{"product_id":"biolegend-150612","title":"Biolegend, 150612, PE\/Cyanine7 anti-mouse CD192 (CCR2) Antibody, 100μg","description":"\u003cp\u003eCD192, also known as CCR2, is a 42 kD G-protein coupled receptor that is associated with bone marrow homeostasis. Specifically, CD192 mediates monocyte chemotaxis and acts as a receptor for monocyte chemoattractant protein 1 (MCP-1). CD192 is primarily expressed on monocytes and macrophages, with some expression on basophils. It is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis and cancer.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CCR2 transfectants.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Li T, et al. 2022. J Leukoc Biol. 112:845. PubMed Shen WY, et al. 2023. iScience. 26:106805. PubMed van Dierendonck XAMH, et al. 2022. Proc Natl Acad Sci U S A. 119:e2114739119. PubMed Zhao M, et al. 2022. Nat Commun. 13:7600. PubMed Karlen SJ, et al. 2018. J Neuroinflammation. 15:344. PubMed Weigert A, et al. 2022. Nat Commun. 13:6078. PubMed Trompette A, et al. 2022. Mucosal Immunol. :. PubMed Canedo T, et al. 2021. Neuropsychopharmacology. 46:2358. PubMed Liu SS, et al. 2021. Immunity. :. PubMed Schmit T, et al. 2022. Cell Rep. 38:110456. PubMed McGinley AM, et al. 2020. Immunity. 52(2):342-356. PubMed Aurélien Trompette et al. 2018. Immunity. 48(5):992-1005 . PubMed\u003cbr\u003e\nRRID: AB_2616983 (BioLegend Cat. No. 150611) AB_2616984 (BioLegend Cat. No. 150612)\u003cbr\u003e\nStructure: G-protein-coupled receptor, 7-transmembrane protein, 42 kD.\u003cbr\u003e\nDistribution: Monocytes\/macrophages and basophils.\u003cbr\u003e\nFunction: Mediator of monocyte chemotaxis and bone marrow homeostasis.\u003cbr\u003e\nLigand\/Receptor: MCP-1, Ccl2, Ccl7, and Ccl13.\u003cbr\u003e\nCell Type: Basophils, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Mack M, et al. 2001. J. Immunol. 166:4697. 2. Dutta P, et al. 2015. Cell Stem Cell. 16:477. 3. Li L, et al. 2008. Kidney Int. 74:1526.\u003cbr\u003e\nGene ID: 12772\u003cbr\u003e\nUniProt: View information about CD192 on UniProt.org\u003cbr\u003e\nClone: SA203G11\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Ccr2, Ckr2, Ccr2a, Ccr2b\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866284380329,"sku":"150612","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-150612","provider":"Iright","version":"1.0","type":"link"}