{"product_id":"biolegend-150903","title":"Biolegend, 150903, PE anti-mouse IL-23R Antibody, 25μg","description":"\u003cp\u003eIL-23R is a 72 kD protein that associates with IL-12RB1 to form a heterodimer. It is a ligand for IL-23 and stimulates T, NK and some myeloid cells.  It is necessary for generation of Th17 cells but is not required for maintenance of previously generated Th17 cells.  Expression of IL-23R or mutations in the IL23R gene has been associated with autoimmunity and may also be important in tumor biology.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial mouse IL-23R recombinant protein (aa 24-374)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Polese B, et al. 2021. Cell Reports. 36(4):109456. PubMed Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed Wang L, et al. 2019. Cell Rep. 29:1848. PubMed Caughron B, et al. 2018. PLoS One. 13:e0196034. PubMed Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed Luo X, et al. 2021. Neuron. 109:2691. PubMed\u003cbr\u003e\nRRID: AB_2572188 (BioLegend Cat. No. 150903) AB_2572189 (BioLegend Cat. No. 150904)\u003cbr\u003e\nStructure: 72 kD protein that associates with IL-12RB1 to form a heterodimer.\u003cbr\u003e\nFunction: Involved in IL-23A signaling.\u003cbr\u003e\nInteraction: JAK2 and STAT3.\u003cbr\u003e\nLigand\/Receptor: IL-23\/IL23A.\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Parham C, et al. 2002. J. Immunol. 168:5699. 2. Schmechel S, et al. 2008. Inflamm. Bowel Dis. 14:204. 3. Harris TJ, et al. 2007. J. Immunol. 179:4313. 4. Zhang XY, et al. 2006. Immunogenetics 57:934. 5. Awasthi A, et al. 2009. J. Immunol. 182:5904.\u003cbr\u003e\nGene ID: 209590\u003cbr\u003e\nUniProt: View information about IL-23R on UniProt.org\u003cbr\u003e\nClone: 12B2B64\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin 23 Receptor, IL-23 Receptor, IL-23R, IBD17\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864327114921,"sku":"150903","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-150903","provider":"Iright","version":"1.0","type":"link"}