{"product_id":"biolegend-153402","title":"Biolegend, 153402, Purified anti-mouse CD125 (IL-5Rα) Antibody, 500μg","description":"\u003cp\u003eCD125 is a 60 kD type I transmembrane protein. It is the ligand-specific α subunit of the heterodimeric interleukin 5 (IL-5) receptor. The signal-transducing β subunit of this receptor does not bind to any cytokines and is shared by the receptors for IL-3 and CSF2\/GM-CSF. IL-5 is mainly produced by Th2 cells and elevated IL-5 levels are associated with allergic disorders. CD125 has also been found to interact with syndecan binding protein (SDCBP or syntenin), leading to the activation of the transcription factor SOX4. The mouse CD125 is expressed on eosinophils, basophils, and B cells.\u003cbr\u003e\n500μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Murine IL-5Ralpha-hFcgamma1 fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Wang Y, et al. 2021. Sci Transl Med. 13:. PubMed\u003cbr\u003e\nRRID: AB_2715827 (BioLegend Cat. No. 153402)\u003cbr\u003e\nStructure: 60 kD type I transmembrane protein\u003cbr\u003e\nDistribution: Eosinophils, basophils and B cells\u003cbr\u003e\nFunction: IL-5 receptor\u003cbr\u003e\nInteraction: JAK2, CD131 (IL3RB, CSF2RB), SDCBP\u003cbr\u003e\nLigand\/Receptor: IL-5\u003cbr\u003e\nCell Type: B cells, Basophils, Eosinophils\u003cbr\u003e\nBiology Area: Cell Biology, Cell Proliferation and Viability, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Takaki S, et al. 1990. EMBO J. 9:4367 2. Takatsu K, et al. 2011. Proc. Jpn. Acad. Ser B. 87:463. 3. Hitoshi Y, et al. 1990. J. Immunol. 144:4218.\u003cbr\u003e\nGene ID: 16192\u003cbr\u003e\nUniProt: View information about CD125 on UniProt.org\u003cbr\u003e\nClone: DIH37\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-5Rα, IL-5 Receptor α subunity\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863009808553,"sku":"153402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-153402","provider":"Iright","version":"1.0","type":"link"}