{"product_id":"biolegend-154608","title":"Biolegend, 154608, PE\/Cyanine7 anti-mouse GPR15\/BOB Antibody, 100μg","description":"\u003cp\u003eGPR15, also known as BOB, is a G-protein coupled receptor with 7 transmembrane regions that is present on the cell surface as a homotrimer. Its ligand, GPR15L, was recently identified. GPR15 is expressed by effector T cells and subsets of memory T cells, and is involved in the recruitment of proinflammatory CD4 + T cells responsible of the pathogenesis in colitis. In humans, GPR15 acts as a receptor for human immunodeficiency virus (HIV) type 1 and 2, and is upregulated on monocytes and neutrophils in the synovia of patients with RA.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse GPR15-Transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2910317 (BioLegend Cat. No. 154607) AB_2910317 (BioLegend Cat. No. 154608)\u003cbr\u003e\nStructure: G-protein coupled receptor\u003cbr\u003e\nDistribution: Effector and memory T cells\u003cbr\u003e\nFunction: Probable chemokine receptor, signal transduction\u003cbr\u003e\nCell Type: T cells, Tregs\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nAntigen References: Nguyen L, et al. 2015. Nature Immunology. 16:207 Kiene M, et al. 2014. PLoS. One. 9:e88195 Cartwright A, et al. 2014. Cytokine. 67:53 Kim SV, et al. 2013. Science. 340:1456 Okamoto Y, et al. 2013. J. Biol. Chem. 288:9189\u003cbr\u003e\nGene ID: 71223\u003cbr\u003e\nUniProt: View information about GPR15\/BOB on UniProt.org\u003cbr\u003e\nClone: S15042I\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: BOB, Brother of Bonzo , G protein-coupled receptor 15, 4933439K08Rik\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866216583337,"sku":"154608","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-154608","provider":"Iright","version":"1.0","type":"link"}