{"product_id":"biolegend-154711","title":"Biolegend, 154711, APC anti-mouse CD204 Antibody, 25μg","description":"\u003cp\u003eCD204, also known as scavenger receptor A (SR-A) and the macrophage scavenger receptor (MSR), is 220 kDa, trimeric type II transmembrane protein, with one scavenger receptor cysteine-rich domain (SRCR). It is a phagocytic pattern-recognition receptor (PRR) expressed on macrophages and dendritic cells. CD204 is a receptor mediating recognition and internalization of low-density lipoprotein (LDL) by macrophages and plays a critical role in atherogenesis. CD204 also recognizes apoptotic cells, modified lipid proteins, and exogenous pathogen-associated molecular patterns (PAMPs), which results in the induction of innate immune and inflammatory responses. CD204 can act as a co-receptor for Toll-like receptors, such as TLR3, TLR4, or TLR9, to facilitate the expression of proinflammatory cytokines. CD204 has been implicated in several pathological processes such as Alzheimer’s disease, sepsis, ischemic injury, and coronary artery disease.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse CD204 extracellular domain\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: This clone has minimal recognition of CD204 in C57BL\/6.\u003cbr\u003e\nRRID: AB_2892311 (BioLegend Cat. No. 154711) AB_2892311 (BioLegend Cat. No. 154712)\u003cbr\u003e\nStructure: Trimeric type II transmembrane protein, one scavenger receptor cysteine-rich domain (SRCR), 220 kD.\u003cbr\u003e\nDistribution: Macrophages, dendritic cells.\u003cbr\u003e\nFunction: Uptake of negatively charged molecules, role in pathology of atherosclerosis and Alzheimer’s disease.\u003cbr\u003e\nLigand\/Receptor: Acetylated and oxidized lipoproteins\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages\u003cbr\u003e\nAntigen References: Shichita T, et al. 2017. Nat Med. 23:723. Muczynski V, et al. 2017. Blood. 129:2443. Iftakhar-E-Khuda I, et al. 2016. Proc Natl Acad Sci U S A. 113:10643. Nellimarla S, et al. 2015. J Immunol. 195:3858. Bonilla DL, et al. 2013. Immunity. 39:537.\u003cbr\u003e\nGene ID: 20288\u003cbr\u003e\nUniProt: View information about CD204 on UniProt.org\u003cbr\u003e\nClone: 1F8C33\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Msr1, MSR, SR-A, Scavenger receptor type A, Macrophage scavenger receptor I, Scara1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864362045609,"sku":"154711","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-154711","provider":"Iright","version":"1.0","type":"link"}