{"product_id":"biolegend-155320","title":"Biolegend, 155320, PE\/Cyanine7 anti-mouse CD163 Antibody, 100μg","description":"\u003cp\u003eCD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI\/61, M130, RM3\/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)\/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem\/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammatory diseases.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse CD163 extracellular domain\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Wang X, et al. 2023. Stem Cell Rev Rep. . PubMed Zhao Y, et al. 2023. Clin Sci (Lond). 1533:137. PubMed Li MX, et al. 2024. Nat Commun. 10539:15. PubMed\u003cbr\u003e\nRRID: AB_2890710 (BioLegend Cat. No. 155319) AB_2890710 (BioLegend Cat. No. 155320)\u003cbr\u003e\nStructure: Type 1 transmembrane glycoprotein, 134 kD (non-reduced)\/155 kD (reduced) glycoprotein\u003cbr\u003e\nDistribution: Macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem\/progenitor cells\u003cbr\u003e\nFunction: Binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nGene ID: 93671\u003cbr\u003e\nUniProt: View information about CD163 on UniProt.org\u003cbr\u003e\nClone: S15049I\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: M130, MM130, SCARI1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866220482729,"sku":"155320","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-155320","provider":"Iright","version":"1.0","type":"link"}