{"product_id":"biolegend-155906","title":"Biolegend, 155906, APC anti-mouse CD183 (CXCR3) Antibody, 100μg","description":"\u003cp\u003eCD183, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca 2+ mobilization and chemotaxis in response to C-X-C chemokines, such as IP10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF4 (CXCL4). CXCR3 is expressed primarily on activiated T lymphocytes, NK cells, and some epithelial cells and endothelial cells. It is not expressed on B cells, monocytes, or granulocytes.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CXCR3-transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Zhang W, et al. 2022. Nat Methods. 19:759. PubMed\u003cbr\u003e\nRRID: AB_2814077 (BioLegend Cat. No. 155905) AB_2814078 (BioLegend Cat. No. 155906)\u003cbr\u003e\nStructure: 38 kD seven pass transmembrane receptor coupled to G-protein.\u003cbr\u003e\nDistribution: T cells, plasmacytoid dendritic cells, GM-CSF activated CD34+ hematopoietic progenitors\u003cbr\u003e\nFunction: Essential in T cell recruitment to sites of inflammation\u003cbr\u003e\nLigand\/Receptor: CXCL10, CXCL9, CXCL11 and CXCL4\u003cbr\u003e\nCell Type: Dendritic cells, Hematopoietic stem and progenitors, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: Farber JM. 1997. J. Leukoc. Biol. 61(3):\\246-57. Bonecchi R, et al. 1998. J. Exp. Med. 187(1):129-34. Aota K, et al. 2018. J. Oral. Pathol. Med. 12756. Kim B, et al. 2018. Data. Brief. 18:518-522. Saahene RO, et al. 2018. Cancer Biother. Radiopharm. 2450.\u003cbr\u003e\nGene ID: 12766\u003cbr\u003e\nUniProt: View information about CD183 on UniProt.org\u003cbr\u003e\nClone: S18001A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CXCR3, G protein-coupled receptor 9 (GPR9), CKR-L2, IP10 receptor (IP10-R), Mig receptor (Mig-R)\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866236637353,"sku":"155906","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-155906","provider":"Iright","version":"1.0","type":"link"}