{"product_id":"biolegend-158011","title":"Biolegend, 158011, PE\/Dazzle™ 594 anti-mouse CD16 Antibody, 25μg","description":"\u003cp\u003eCD16 also know as Fcgr3 is a 50-65 kD type I transmembrane protein, member of the Fc gamma receptor family and  Ig superfamily. CD16  is expressed  on most myeloid cells including monocytes, macrophages, dendritic cells, and is also expressed by NK cells and NKT cells. CD16 is involved in cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC); its ligands are IgG1, IgG2a and IgG2b.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CD16 - transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Dazzle™ 594 under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * PE\/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm. Clone S17014E does not cross-react with CD32 or CD64.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Anti-mouse CD16\/32 clones 93 and 2.4G2 both block clone S17014E staining.\u003cbr\u003e\nRRID: AB_2876543 (BioLegend Cat. No. 158011) AB_2876543 (BioLegend Cat. No. 158012)\u003cbr\u003e\nStructure: Type I transmembrane protein, 50-65 kDa; member of the Fc gamma receptor family and Ig superfamily\u003cbr\u003e\nDistribution: Expressed on most myeloid cells including monocytes, macrophages, dendritic cells; also on NK cells and NKT cells\u003cbr\u003e\nFunction: Fc receptor, involved in cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).\u003cbr\u003e\nLigand\/Receptor: IgG1, IgG2a and IgG2b\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages, Monocytes, Neutrophils, NK cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules, Fc Receptors\u003cbr\u003e\nAntigen References: Nimmerjahn F1 \u0026amp; Ravetch JV. 2008. Nat Rev Immunol. 8(1):34-47. Biburger M \u0026amp; Nimmerjahn F. 2012. Immunol Lett. 143(1):53-9. Arase N, et al. 2003. J Immunol. 170:3054.\u003cbr\u003e\nGene ID: 14131\u003cbr\u003e\nUniProt: View information about CD16 on UniProt.org\u003cbr\u003e\nClone: S17014E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Fcgr3, Fc receptor, IgG, low affinity III, Fc gamma receptor, Fc gamma receptor 3\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866232180905,"sku":"158011","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-158011","provider":"Iright","version":"1.0","type":"link"}