{"product_id":"biolegend-159302","title":"Biolegend, 159302, Purified anti-mouse CD86 Antibody, 500μg","description":"\u003cp\u003eCD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.\u003cbr\u003e\n500μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse CD86\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone A17199H is able to block the staining of clone PO3. This clone is able to block the interaction between CD86 and CD28.\u003cbr\u003e\nRRID: AB_2888740 (BioLegend Cat. No. 159302)\u003cbr\u003e\nStructure: Ig superfamily, 80 kD\u003cbr\u003e\nDistribution: B cells and T cells (upregulated upon activation), macrophages, dendritic cells, and astrocytes\u003cbr\u003e\nFunction: T cell costimulation, Ig class-switching, NK cell cytotoxicity\u003cbr\u003e\nInteraction: Astrocytes, B cells, Dendritic cells, Macrophages, T cells, Tregs\u003cbr\u003e\nLigand\/Receptor: CD28, CD152 (CTLA-4)\u003cbr\u003e\nAntigen References: 1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Hathcock KS, et al. 1993. Science 262:905. 3. Freeman GJ, et al. 1993. Science 262:907. 4. Carreno BM, et al. 2002. Annu. Rev. Immunol. 20:29.\u003cbr\u003e\nGene ID: 12524\u003cbr\u003e\nUniProt: View information about CD86 on UniProt.org\u003cbr\u003e\nClone: A17199H\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: B7-2, B70, Ly-58\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866057199785,"sku":"159302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-159302","provider":"Iright","version":"1.0","type":"link"}