{"product_id":"biolegend-160708","title":"Biolegend, 160708, KIRAVIA Blue 520™ anti-mouse IL-31 Antibody, 100μg","description":"\u003cp\u003eIL-31, mainly produced by activated CD4+ T cells, is a helical cytokine belonging to the gp130\/IL-6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK\/STAT, PI3K\/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Transgenic mice overexpressing IL-31 developed severe dermatitis, indicating that IL-31 is involved in skin immunity.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse IL-31\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with KIRAVIA Blue 520™ under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * KIRAVIA Blue 520™ has an excitation maximum of 495 nm, and a maximum emission of 520 nm. KIRAVIA Blue™ 520 is a trademark of Sony. This product is subject to proprietary rights of Sony and is made and sold under license from Sony Corporation. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.Sony and the Sony logo are registered trademarks of Sony Corporation.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nRRID: AB_2910332 (BioLegend Cat. No. 160707) AB_2910332 (BioLegend Cat. No. 160708)\u003cbr\u003e\nStructure: Member of IL-6 family of cytokines\u003cbr\u003e\nDistribution: Subset of CD4 T cells\u003cbr\u003e\nLigand\/Receptor: IL-31Ra\/OSMR\u003cbr\u003e\nCell Type: Lymphocytes, T cells, Th2, Thymocytes\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: McCandless EE, et al. 2014. Vet. Immunol. Immunopathol. 157:42. Arai I, et al. 2013. Exp. Dermatol. 22:669. Dai X, et al. 2013. PLoS One. 8:e67666. Stott B, et al. 2013. J. Allergy Clin. Immunol. 132:446. Hartmann K, et al. 2013. J. Allergy Clin. Immunol. 132:232. Baron JM and Lüscher B. 2012. Acta. Derm. Venereol. 92:5\u003cbr\u003e\nGene ID: 76399\u003cbr\u003e\nUniProt: View information about IL-31 on UniProt.org\u003cbr\u003e\nClone: W17037B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin-31\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866310856873,"sku":"160708","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-160708","provider":"Iright","version":"1.0","type":"link"}