{"product_id":"biolegend-162603","title":"Biolegend, 162603, APC anti-mouse CD150 (SLAM) Antibody, 25μg","description":"\u003cp\u003eCD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: RBL1 transfectant (1-287a.a)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_2910343 (BioLegend Cat. No. 162603) AB_2910343 (BioLegend Cat. No. 162604)\u003cbr\u003e\nStructure: Ig superfamily, 75-95 kD\u003cbr\u003e\nDistribution: Thymocytes, T cell subset, B lymphocytes, dendritic cells, endothelial cells\u003cbr\u003e\nFunction: B cell and dendritic cell costimulation\u003cbr\u003e\nLigand\/Receptor: CD150\u003cbr\u003e\nAntigen References: 1. Punnonen J, et al. 1997. J. Exp. Med. 185:993. 2. Gordiienko I, et al. 2019. Clin Immunol. 204:14-22 3. Kiel M, et al. 2005. Cell. 121(7):1109-21\u003cbr\u003e\nGene ID: 27218\u003cbr\u003e\nUniProt: View information about CD150 on UniProt.org\u003cbr\u003e\nClone: W19132B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: SignalingLymphocyte Activation Molecule (SLAM), IPO-3\u003cbr\u003e\nIsotype: Rat IgG2a, λ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866345689257,"sku":"162603","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-162603","provider":"Iright","version":"1.0","type":"link"}