{"product_id":"biolegend-163103","title":"Biolegend, 163103, Alexa Fluor® 647 anti-mouse CD36L Antibody, 25μg","description":"\u003cp\u003eScavenger receptor class B type I (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. It is an integral membrane protein and function as HDL receptor expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway. Its primary function is facilitating reverse cholesterol transport by transferring cholesterol esters of high-density lipoproteins (HDLs) into the liver. This function serves to lower the risk of development of atherosclerosis. SCARB1 is also able to bind to other lipoproteins such as LDL, OxLDL, and VLDL. SCARB1 is also likely to be involved in pathogen recognition through its recognition of mycobacteria and other viral proteins and regulates vitamin E levels in the tissue.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: IHC-F - Quality tested FC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration of 5.0 µg\/mL is suggested. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): 1. Tsugita M. et al. 2017. Cell Rep. 18:1298.\u003cbr\u003e\nRRID: AB_3105988 (BioLegend Cat. No. 163103) AB_3105988 (BioLegend Cat. No. 163104)\u003cbr\u003e\nStructure: Integral membrane glycoprotein\u003cbr\u003e\nDistribution: Liver and nonplacental steroidogenic tissues\u003cbr\u003e\nFunction: Involved in the uptake of high density lipoproteins (HDL), phagocytosis of apoptotic cells, and pathogen recognition.\u003cbr\u003e\nLigand\/Receptor: Phosphatidylserine, HDL, apoB-containing lipoproteins, LDL, vitamin E\u003cbr\u003e\nCell Type: Macrophages, Monocytes, Platelets\u003cbr\u003e\nBiology Area: Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Acton S, et al. 1996. Science. 5248:518. Rigotti A, et al. 2003. Endocr Rev. 24:357. Valacchi G, et al. 2011. Ann N Y Acad Sci. 1229:E1-7. Scarselli E, et al. 2002. EMBO J. 21:5017. Mardones P, et al. 2002. J Nutr. 132:443.\u003cbr\u003e\nGene ID: 20778\u003cbr\u003e\nUniProt: View information about CD36L on UniProt.org\u003cbr\u003e\nClone: AOB-1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: SCARB1, SR-BI\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862540243113,"sku":"163103","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-163103","provider":"Iright","version":"1.0","type":"link"}