{"product_id":"biolegend-164702","title":"Biolegend, 164702, Purified anti-mouse CD8a Antibody, 100μg","description":"\u003cp\u003eCD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)\/β(CD8b) heterodimer and α\/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α\/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α\/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α\/α homodimer is expressed on a subset of γ\/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse CD8a\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-F - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 5.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2910346 (BioLegend Cat. No. 164702)\u003cbr\u003e\nStructure: Ig superfamily, CD8α chain, 34 kD\u003cbr\u003e\nDistribution: Most thymocytes, T cell subset, some NK cells, lymphoid dendritic cells\u003cbr\u003e\nFunction: Co-receptor for TCR\u003cbr\u003e\nLigand\/Receptor: MHC class I molecule\u003cbr\u003e\nCell Type: Dendritic cells, NK cells, T cells, Thymocytes, Tregs\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Ledbetter JA, et al. 1979. Immunol Rev. 47:63-90. Hathcock KS. 1991. Current Protocols in Immunology. 3.4.1. Takahashi K, et al. 1992. Proc Natl Acad Sci USA. 89:5557-61. Ledbetter JA, et al. 1981. J Exp Med. 153:1503-16. Hata H, et al. 2004. J Clin Invest. 114:582-8. Fan WY, et al. 2001. Exp Biol Med. 226:1045-50. Shih FF, et al. 2006. J Immunol. 176:3438-48. Kamimura D, et al. 2006. J Immunol. 177:306-14. Bouwer HGA, et al. 2006. Proc Natl Acad Sci USA. 103:5102-7. Kao C, et al. 2005. Int Immunol. 17:1607-17. Ko SY, et al. 2005. J Immunol. 175:3309-17. Rasmussen JW, et al. 2006. Infect Immun. 74:6590-8.\u003cbr\u003e\nGene ID: 12525\u003cbr\u003e\nUniProt: View information about CD8a on UniProt.org\u003cbr\u003e\nClone: S18018A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T8, Lyt2, Ly-2\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866251317417,"sku":"164702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-164702","provider":"Iright","version":"1.0","type":"link"}