{"product_id":"biolegend-165302","title":"Biolegend, 165302, Purified anti-mouse IL-33Rα (IL1RL1, ST2) Antibody, 100μg","description":"\u003cp\u003eIL-33Rα, also known as ST2 or IL-1RL1, is a member of the Toll\/IL-1 receptor family. It binds IL-33 and is structurally similar to IL-1R1. Two forms of the protein exist: a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. Signaling through IL1RL1 drives cytokine production in mast cells, basophils, eosinophils, invariant NKT and NK cells, Th2 lymphocytes, and type 2 innate immune cells. IL-33 signaling is required for maintaining the suppressive function of regulatory T cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse IL-33Rα, AA 27-342\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2922503 (BioLegend Cat. No. 165302)\u003cbr\u003e\nStructure: Single-pass type I membrane protein\u003cbr\u003e\nDistribution: Th2 lymphocytes, mast cells, fibroblasts\u003cbr\u003e\nFunction: Following interaction with IL-33, it recruits MyD88, Irak1, Irak4 and Traf6 followed by phosphorylation of the MAP\/ERK pathway\u003cbr\u003e\nInteraction: Interacts with MyD88, Irak1, Irak4 and Traf6\u003cbr\u003e\nLigand\/Receptor: IL-33\u003cbr\u003e\nCell Type: Fibroblasts, Mast cells, Th2\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: Yanagisawa K, et al. 1993. FEBS Lett. 318:83-7. Schmitt E, et al. 1990. Cytokine. 2:407-15. Yanagisawa K, et al. 1992. FEBS Lett. 302:51-3. Takagi T, et al. 1993. Biochim Biophys Acta. 1178:194-200.\u003cbr\u003e\nGene ID: 9173\u003cbr\u003e\nUniProt: View information about IL-33Ralpha on UniProt.org\u003cbr\u003e\nClone: W17243F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-33R, ST2, IL-1RL1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866328289449,"sku":"165302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-165302","provider":"Iright","version":"1.0","type":"link"}