{"product_id":"biolegend-166310","title":"Biolegend, 166310, APC anti-mouse Integrin αVβ6 Antibody, 100μg","description":"\u003cp\u003eIntegrins are heterodimeric transmembrane receptors that mediate cell-cell and cell-extracellular matrix adhesion. Integrin β6 associates exclusively with the αV subunit forming an αVβ6 complex that is expressed specifically on epithelial cells. Integrin αVβ6 is a receptor for multiple extracellular matrix (ECM) proteins, including tenascin, fibronectin, and vitronectin. It is also a receptor for the latency-associated peptide (LAP) of TGF-β and is involved in TGF-β activation. Its expression is upregulated during wound healing and in some cancers.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse αVβ6 integrin-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Clone S20012E does not affect the binding of clone S20012B on target cells. Clone S20012E does not react with mouse integrin αVβ8.\u003cbr\u003e\nRRID: AB_3698933 (BioLegend Cat. No. 166309) AB_3698933 (BioLegend Cat. No. 166310)\u003cbr\u003e\nStructure: Integrins\u003cbr\u003e\nDistribution: Epithelial cells\u003cbr\u003e\nFunction: Cell adhesion, TGF-β activation\u003cbr\u003e\nCell Type: Epithelial cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: Sheppard D, et al 1990. J Biol Chem. 265:11502-7. Koivisto L, et al. 2018. Int J Biochem Cell Biol. 99:186-196.\u003cbr\u003e\nGene ID: 1641016420\u003cbr\u003e\nUniProt: View information about Integrin alphaVbeta6 on UniProt.org\u003cbr\u003e\nClone: S20012E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Integrin alpha V beta 6\u003cbr\u003e\nIsotype: Rat IgG2b, λ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866265473193,"sku":"166310","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-166310","provider":"Iright","version":"1.0","type":"link"}