{"product_id":"biolegend-302102","title":"Biolegend, 302102, Purified anti-human CD18 Antibody, 100μg","description":"\u003cp\u003eCD18 is a 90-95 kD type I transmembrane protein also known as integrin β 2 subunit, LFA-1 β subunit, and β 2 integrin. CD18 non-covalently associates with CD11a, CD11b or CD11c. CD18 is expressed on all leukocytes. CD18 and associated α chains function in adhesion and signaling in hematopoietic cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Pig\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested Block - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: inhibition of cell adhesion and migration3,4. The Ultra-LEAF™ purified antibody (Endotoxin \u0026lt; 0.01 EU\/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 302116) is recommended for functional assays.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Schlossman S, et al. 1995. Leucocyte Typing V. Oxford University Press. New York. Kishimoto T, et al. 1997. Leucocyte Typing VI. Garland Press. London. Van Epps DE, et al. 1989. J. Immunol. 143:3207. (Block) Meerschaert J, et al. 1994. J. Immunol. 152:1915. (Block) Sithu SD, et al. 2007. J. Biol. Chem. doi:10.1074\/jbc.M611273200. Sommaggio R, et al. 2012. J. Immunol. 188:2075. PubMed Valenzuela NM, et al. 2013. J. Immunol. 190:6635. PubMed\u003cbr\u003e\nProduct Citations: Mascarau R, et al. 2023. J Cell Biol. 222:. PubMed Kirolos SA, et al. 2022. J Leukoc Biol. 112:1399. PubMed Gong YY, et al. 2022. Cancer Res Commun. 2:842. PubMed Zhang W, et al. 2022. Dev Cell. 57:329. PubMed Hosoki K, et al. 2012. J Leukoc Biol. 92:333. PubMed Nakayama H, et al. 2008. J Leukoc Biol. 83:728. PubMed Sommaggio R, et al. 2012. J Immunol. 188:2075. PubMed Tran D, et al. 2009. J Immunol. 182:2929. PubMed Kolev M, et al. 2020. Immunity. 52(3):513-527. PubMed Chakrabarty S, et al. 2011. Blood. 117:1585. PubMed\u003cbr\u003e\nRRID: AB_314220 (BioLegend Cat. No. 302102)\u003cbr\u003e\nStructure: Integrin, type I transmembrane glycoprotein, associates with CD11a, CD11b, or CD11c, 90-95 kD\u003cbr\u003e\nDistribution: Leukocytes\u003cbr\u003e\nFunction: Adhesion and signaling in hematopoietic system\u003cbr\u003e\nLigand\/Receptor: ICAMs\u003cbr\u003e\nCell Type: Leukocytes, Tregs\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Anderson D, et al. 1987. Annu. Rev. Med. 38:175. 2. Springer T. 1994. Cell 76:301.\u003cbr\u003e\nGene ID: 3689\u003cbr\u003e\nUniProt: View information about CD18 on UniProt.org\u003cbr\u003e\nClone: TS1\/18\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: V AS162\u003cbr\u003e\nOther Names: Integrin β2 subunit, LFA -1 β subunit, β2 integrin, ITGB2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864010608809,"sku":"302102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-302102","provider":"Iright","version":"1.0","type":"link"}