{"product_id":"biolegend-303806","title":"Biolegend, 303806, Spark Violet™ 538 anti-human CD8 Recombinant Antibody, 100tests","description":"\u003cp\u003eCD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a\/a) or heterodimer (CD8a\/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: PROPRIETARY\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Spark Violet™ 538 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * Spark Violet™ 538 has a maximum excitation of 396 nm and a maximum emission of 545 nm.\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nRRID: AB_2890736 (BioLegend Cat. No. 303805) AB_2890736 (BioLegend Cat. No. 303806)\u003cbr\u003e\nStructure: reIg superfamily, homodimer or heterodimer with CD8b, 32-34 kD\u003cbr\u003e\nDistribution: Majority of thymocytes, T cell subset, NK cells\u003cbr\u003e\nLigand\/Receptor: MHC Class I molecules\u003cbr\u003e\nCell Type: NK cells, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Barclay N, et al. 1993. The Leucocyte Antigen FactsBook. Academic Press Inc. San Diego.\u003cbr\u003e\nGene ID: 925\u003cbr\u003e\nUniProt: View information about CD8 on UniProt.org\u003cbr\u003e\nClone: QA18A37\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T8, Leu2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866182602921,"sku":"303806","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-303806","provider":"Iright","version":"1.0","type":"link"}