{"product_id":"biolegend-304603","title":"Biolegend, 304603, FITC anti-human CD56 (NCAM) Antibody, 25tests","description":"\u003cp\u003eCD56 is a single transmembrane glycoprotein also known as N-CAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Cow, Pig\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: KG-1 human acute myelogenous leukemia cell line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation, immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections, and Western blotting (non-reducing).\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.\u003cbr\u003e\nProduct Citations: Choi S, et al. 2022. EMBO Mol Med. 14:e14526. PubMed Hamdan F, et al. 2023. Mol Ther Oncolytics. 28:264. PubMed Asashima H, et al. 2022. J Clin Invest. 132: . PubMed Kerr SC, et al. 2020. Clin Exp Allergy. 50:904. PubMed Sugita S, et al. 2016. Stem Cell Reports. 7:619-634. PubMed Xia Y, et al. 2019. Gastroenterol Res Pract. 2019:5436961. PubMed Santana-Codina N, et al. 2013. Mol Cell Proteomics. 12:2111. PubMed Vardam-Kaur T, et al. 2021. Oncotarget. 12:2051. PubMed Janela B, et al. 2019. Immunity. 50:1069. PubMed Fujii S, et al. 2019. Stem Cells Dev. 28:28. PubMed Krishnan S, et al. 2021. Clin Exp Immunol. 203:458. PubMed Lu J, et al. 2021. Front Immunol. 12:732612. PubMed Mishra A, et al. 2021. Cell. 184(13):3394-3409.e20. PubMed Foote JR, et al. 2019. Front Immunol. 10:188. PubMed Hamdan F, et al. 2021. Journal for ImmunoTherapy of Cancer. 9(8):. PubMed Siegers G, et al. 2011. PLoS One. 6:e16700. PubMed\u003cbr\u003e\nRRID: AB_314445 (BioLegend Cat. No. 304603) AB_314446 (BioLegend Cat. No. 304604)\u003cbr\u003e\nStructure: Ig superfamily, single transmembrane or GPI-anchored glycoprotein, 175-185 kD\u003cbr\u003e\nDistribution: NK cells, T subset, neural tissue, some LGL and myeloid leukemias\u003cbr\u003e\nFunction: Adhesion\u003cbr\u003e\nLigand\/Receptor: Heparin sulfate\u003cbr\u003e\nCell Type: Leukemia, Mesenchymal Stem Cells, Neurons, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Lanier L, et al. 1991. J. Immunol. 146:4421. 2. Hemperly J, et al. 1990. J. Mol. Neurosci. 2:71. 3. Cremer H, et al. 1994. Nature 367:455.\u003cbr\u003e\nGene ID: 4684\u003cbr\u003e\nUniProt: View information about CD56 on UniProt.org\u003cbr\u003e\nClone: MEM-188\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VI NK26\u003cbr\u003e\nOther Names: NCAM, Leu-19, NKH1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866463228073,"sku":"304603","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-304603","provider":"Iright","version":"1.0","type":"link"}